Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse models

Many inbred strains of mice develop spontaneous tumors as they age. Recent awareness of the impacts of mitochondrial DNA (mtDNA) on cancer and aging has inspired developing a mitochondrial-nuclear exchange (MNX) mouse model in which nuclear DNA is paired with mitochondrial genomes from other strains...

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Veröffentlicht in:	Cancer and metastasis reviews 2018-12, Vol.37 (4), p.633-642
Hauptverfasser:	Vivian, Carolyn J., Hagedorn, Travis M., Jensen, Roy A., Brinker, Amanda E., Welch, Danny R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Analysis Animal models Animals Biomedical and Life Sciences Biomedicine Cancer Cancer Research DNA, Mitochondrial - genetics Female Genes Genetic aspects Genetic engineering Genomes Genomics Inbreeding Male Metastases Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mitochondria - genetics Mitochondrial DNA Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Oncology Phenotype Phenotypes Polymorphism, Single Nucleotide Rodents Transgenic mice Tumorigenicity Tumors
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