Comparison of Chlorantraniliprole and Flubendiamide Activity Toward Wild-Type and Malignant Hyperthermia-Susceptible Ryanodine Receptors and Heat Stress Intolerance

Abstract Chlorantraniliprole (CP) and flubendiamide (FD) are widely used in agriculture globally to control lepidopteran pests. Both insecticides target ryanodine receptors (RyRs) and promote Ca2+ leak from sarcoplasmic reticulum (SR) within insect skeletal muscle yet are purportedly devoid of activ...

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Veröffentlicht in:	Toxicological sciences 2019-02, Vol.167 (2), p.509-523
Hauptverfasser:	Truong, Kim M, Pessah, Isaac N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - toxicity Calcium - metabolism Dose-Response Relationship, Drug Heat-Shock Response - drug effects Heat-Shock Response - genetics Heterozygote Homozygote Male Malignant Hyperthermia - genetics Malignant Hyperthermia - metabolism Mice Mice, Inbred C57BL Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Mutation ortho-Aminobenzoates - toxicity Protein Binding Rabbits Ryanodine Receptor Activation and Malignant Hyperthermia Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Sulfones - toxicity
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