Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations
Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of d...
Gespeichert in:
| Veröffentlicht in: | Acta bio-medica de l'Ateneo Parmense 2017-10, Vol.88 (4S), p.5-10 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | 4S |
| container_start_page | 5 |
| container_title | Acta bio-medica de l'Ateneo Parmense |
| container_volume | 88 |
| creator | Dall'Oca, C Cengarle, M Costanzo, A Giannini, N Vacchiano, A Magnan, B |
| description | Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined. |
| doi_str_mv | 10.23750/abm.v88i4-S.6788 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6357662</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1957767094</sourcerecordid><originalsourceid>FETCH-LOGICAL-p181t-f9a95529c57b6477b93a00e781ad5b584c091d47b8a9ed20abd280c8d01e062f3</originalsourceid><addsrcrecordid>eNpVkEuLFDEUhYMoTs_oD3AjWbqpNu8HgiCNOsKAC3Vd3Erd7o5WJW2SGhh_vdXMKLq6cM7hO4dLyAvOtkJazV7DMG9vnYuq-7I11rlHZCO05J2xSj8mGya96JRg8oJc1vqdMaO14k_JhfDMSanshvzaLaVgajTkFPDUKo2JtoLQ5rOa9xShTHf0R0KkuTbMUNqxxBYrhTTeS-GY01hgohPWmFN9Q9sRackTngFDzFM-xLD6sBzOWGjn1DPyZA9TxecP94p8-_D-6-66u_n88dPu3U134o63bu_Bay180HYwytrBS2AMreMw6kE7FZjno7KDA4-jYDCMwrHgRsaRGbGXV-TtPfe0DDOOYR2wbu1PJc5Q7voMsf_fSfHYH_Jtb6S2xogV8OoBUPLPBWvr51gDThMkzEvtudfWGsu8WqMv_-36W_Ln4fI31qeIDg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1957767094</pqid></control><display><type>article</type><title>Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Dall'Oca, C ; Cengarle, M ; Costanzo, A ; Giannini, N ; Vacchiano, A ; Magnan, B</creator><creatorcontrib>Dall'Oca, C ; Cengarle, M ; Costanzo, A ; Giannini, N ; Vacchiano, A ; Magnan, B</creatorcontrib><description>Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined.</description><identifier>ISSN: 0392-4203</identifier><identifier>EISSN: 2531-6745</identifier><identifier>DOI: 10.23750/abm.v88i4-S.6788</identifier><identifier>PMID: 29083347</identifier><language>eng</language><publisher>Italy: Mattioli 1885</publisher><subject>Chondrocytes - transplantation ; Humans ; Intra-Articular Fractures ; Mesenchymal Stem Cell Transplantation ; Osteoarthritis, Knee - therapy ; Platelet-Rich Plasma ; Review</subject><ispartof>Acta bio-medica de l'Ateneo Parmense, 2017-10, Vol.88 (4S), p.5-10</ispartof><rights>Copyright: © 2017 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357662/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357662/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29083347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dall'Oca, C</creatorcontrib><creatorcontrib>Cengarle, M</creatorcontrib><creatorcontrib>Costanzo, A</creatorcontrib><creatorcontrib>Giannini, N</creatorcontrib><creatorcontrib>Vacchiano, A</creatorcontrib><creatorcontrib>Magnan, B</creatorcontrib><title>Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations</title><title>Acta bio-medica de l'Ateneo Parmense</title><addtitle>Acta Biomed</addtitle><description>Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined.</description><subject>Chondrocytes - transplantation</subject><subject>Humans</subject><subject>Intra-Articular Fractures</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Osteoarthritis, Knee - therapy</subject><subject>Platelet-Rich Plasma</subject><subject>Review</subject><issn>0392-4203</issn><issn>2531-6745</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEuLFDEUhYMoTs_oD3AjWbqpNu8HgiCNOsKAC3Vd3Erd7o5WJW2SGhh_vdXMKLq6cM7hO4dLyAvOtkJazV7DMG9vnYuq-7I11rlHZCO05J2xSj8mGya96JRg8oJc1vqdMaO14k_JhfDMSanshvzaLaVgajTkFPDUKo2JtoLQ5rOa9xShTHf0R0KkuTbMUNqxxBYrhTTeS-GY01hgohPWmFN9Q9sRackTngFDzFM-xLD6sBzOWGjn1DPyZA9TxecP94p8-_D-6-66u_n88dPu3U134o63bu_Bay180HYwytrBS2AMreMw6kE7FZjno7KDA4-jYDCMwrHgRsaRGbGXV-TtPfe0DDOOYR2wbu1PJc5Q7voMsf_fSfHYH_Jtb6S2xogV8OoBUPLPBWvr51gDThMkzEvtudfWGsu8WqMv_-36W_Ln4fI31qeIDg</recordid><startdate>20171018</startdate><enddate>20171018</enddate><creator>Dall'Oca, C</creator><creator>Cengarle, M</creator><creator>Costanzo, A</creator><creator>Giannini, N</creator><creator>Vacchiano, A</creator><creator>Magnan, B</creator><general>Mattioli 1885</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171018</creationdate><title>Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations</title><author>Dall'Oca, C ; Cengarle, M ; Costanzo, A ; Giannini, N ; Vacchiano, A ; Magnan, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p181t-f9a95529c57b6477b93a00e781ad5b584c091d47b8a9ed20abd280c8d01e062f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Chondrocytes - transplantation</topic><topic>Humans</topic><topic>Intra-Articular Fractures</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Osteoarthritis, Knee - therapy</topic><topic>Platelet-Rich Plasma</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dall'Oca, C</creatorcontrib><creatorcontrib>Cengarle, M</creatorcontrib><creatorcontrib>Costanzo, A</creatorcontrib><creatorcontrib>Giannini, N</creatorcontrib><creatorcontrib>Vacchiano, A</creatorcontrib><creatorcontrib>Magnan, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta bio-medica de l'Ateneo Parmense</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dall'Oca, C</au><au>Cengarle, M</au><au>Costanzo, A</au><au>Giannini, N</au><au>Vacchiano, A</au><au>Magnan, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations</atitle><jtitle>Acta bio-medica de l'Ateneo Parmense</jtitle><addtitle>Acta Biomed</addtitle><date>2017-10-18</date><risdate>2017</risdate><volume>88</volume><issue>4S</issue><spage>5</spage><epage>10</epage><pages>5-10</pages><issn>0392-4203</issn><eissn>2531-6745</eissn><abstract>Early knee osteoarthritis and chondral lesions are a common cause of disability in younger patients. Surgical options, such as microfractures, ACI and OAT, provide good, but not fully satisfying, outcomes. Recent advance in biological knowledge introduced two different methodological approaches of delivering growth factors and stem cells into the articular environment. Platelet-Rich Plasma and Mesenchimal Stem Cells are supposed to change the way to approach early knee osteoarthritis and chondral lesions, though their indications and limits are yet to be determined.</abstract><cop>Italy</cop><pub>Mattioli 1885</pub><pmid>29083347</pmid><doi>10.23750/abm.v88i4-S.6788</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0392-4203 |
| ispartof | Acta bio-medica de l'Ateneo Parmense, 2017-10, Vol.88 (4S), p.5-10 |
| issn | 0392-4203 2531-6745 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6357662 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Chondrocytes - transplantation Humans Intra-Articular Fractures Mesenchymal Stem Cell Transplantation Osteoarthritis, Knee - therapy Platelet-Rich Plasma Review |
| title | Current concepts in treatment of early knee osteoarthritis and osteochondral lesions; the role of biological augmentations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A26%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Current%20concepts%20in%20treatment%20of%20early%20knee%20osteoarthritis%20and%20osteochondral%20lesions;%20the%20role%20of%20biological%20augmentations&rft.jtitle=Acta%20bio-medica%20de%20l'Ateneo%20Parmense&rft.au=Dall'Oca,%20C&rft.date=2017-10-18&rft.volume=88&rft.issue=4S&rft.spage=5&rft.epage=10&rft.pages=5-10&rft.issn=0392-4203&rft.eissn=2531-6745&rft_id=info:doi/10.23750/abm.v88i4-S.6788&rft_dat=%3Cproquest_pubme%3E1957767094%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1957767094&rft_id=info:pmid/29083347&rfr_iscdi=true |