AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells

The serine-threonine kinase AKT/PKB is a critical regulator of various essential cellular processes, and dysregulation of AKT has been implicated in many diseases, including cancer. Despite AKT action is known to function mainly in the cytoplasm, AKT has been reported to translocate to the nucleus....

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Veröffentlicht in:	Bioscience reports 2019-01, Vol.39 (1)
Hauptverfasser:	Coa, Larissa Leggieri, Abreu, Thiago Ferreira, Tashima, Alexandre Keiji, Green, Janaina, Pascon, Renata Castiglioni, Vallim, Marcelo Afonso, Machado-Jr, Joel
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Active Transport, Cell Nucleus - genetics Cell Nucleus - genetics Cell Nucleus - metabolism Cytoplasm - genetics Gene Expression Regulation, Neoplastic Heterogeneous-Nuclear Ribonucleoproteins - genetics Humans Melanoma - genetics Melanoma - pathology Oncogene Protein v-akt - genetics Phosphorylation Protein Binding RNA Polymerase II - genetics Signal Transduction - genetics Transcription, Genetic
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