The KV7 channel activator retigabine suppresses mouse urinary bladder afferent nerve activity without affecting detrusor smooth muscle K+ channel currents

Key points KV7 channels are a family of voltage‐dependent K+ channels expressed in many cell types, which open in response to membrane depolarization to regulate cell excitability. Drugs that target KV7 channels are used clinically to treat epilepsy. Interestingly, these drugs also cause urinary ret...

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Veröffentlicht in:The Journal of physiology 2019-02, Vol.597 (3), p.935-950
Hauptverfasser: Tykocki, Nathan R., Heppner, Thomas J., Dalsgaard, Thomas, Bonev, Adrian D., Nelson, Mark T.
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Sprache:eng
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