Multicenter Population Pharmacokinetic Study of Colistimethate Sodium and Colistin Dosed as in Normal Renal Function in Patients on Continuous Renal Replacement Therapy

Intravenous colistimethate sodium (CMS) is used to treat infections with multiresistant Gram-negative bacteria. Optimal dosing in patients undergoing continuous renal replacement therapy (CRRT) is unclear. In a prospective study, we determined CMS and colistin pharmacokinetics in 10 critically ill p...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-02, Vol.63 (2)
Hauptverfasser:	Leuppi-Taegtmeyer, Anne B, Decosterd, Laurent, Osthoff, Michael, Mueller, Nicolas J, Buclin, Thierry, Corti, Natascia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-Bacterial Agents Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Chromatography, Liquid Colistin Colistin - analogs & derivatives Colistin - pharmacokinetics Colistin - therapeutic use Continuous Renal Replacement Therapy Continuous Renal Replacement Therapy - methods Escherichia coli - drug effects Escherichia coli Infections Escherichia coli Infections - drug therapy Escherichia coli Infections - mortality Female Humans Male Mass Spectrometry Middle Aged Pharmacology Prospective Studies Pseudomonas aeruginosa - drug effects Pseudomonas Infections Pseudomonas Infections - drug therapy Pseudomonas Infections - mortality
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