Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malari...

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Veröffentlicht in:	EBioMedicine 2019-01, Vol.39, p.358-368
Hauptverfasser:	Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, Mbulaiteye, Sam M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Africa Antibodies, Protozoan - metabolism Binding Sites Burkitt lymphoma Burkitt Lymphoma - immunology Burkitt Lymphoma - parasitology Case-Control Studies Child Child, Preschool Epstein-Barr virus Female Ghana Humans Immunoglobulin G - metabolism Infant Infant, Newborn Logistic Models Malaria, Falciparum - immunology Male Non-Hodgkin lymphoma Odds Ratio PfEMP1 Plasmodium falciparum - immunology Plasmodium falciparum - metabolism Plasmodium falciparum malaria Protozoan Proteins - chemistry Protozoan Proteins - immunology Research paper Uganda
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