Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely attributed to the release of soluble mediators and reactive oxygen species (ROS). We identified what we believe is a...

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Veröffentlicht in:	The Journal of clinical investigation 2019-02, Vol.129 (2), p.712-726
Hauptverfasser:	Butin-Israeli, Veronika, Bui, Triet M, Wiesolek, Hannah L, Mascarenhas, Lorraine, Lee, Joseph J, Mehl, Lindsey C, Knutson, Kaitlyn R, Adam, Stephen A, Goldman, Robert D, Beyder, Arthur, Wiesmuller, Lisa, Hanauer, Stephen B, Sumagin, Ronen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical research Biotechnology Cancer Colitis - metabolism Colitis - pathology Colon - injuries Colon - metabolism Colon - pathology Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage Epithelial cells Epithelium Female Gastrointestinal diseases Gene expression Genomic Instability Genomics Health aspects Homeostasis Homologous recombination Humans Inflammation Inflammation - metabolism Inflammation - pathology Inflammatory bowel disease Inflammatory bowel diseases Intestine Male Mice Microparticles MicroRNA MicroRNAs MicroRNAs - metabolism miRNA Mucosa Neutrophils Neutrophils - metabolism Neutrophils - pathology Rad51 Recombinase - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Senescence Wound care Wound Healing
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