Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

Graft-versus-host disease (GVHD) is a complication of hematopoietic stem cell transplantation (HSCT) that affects multiple organs. GVHD-associated intestinal damage can be separated into two distinct phases, initiation and propagation, which correspond to conditioning-induced damage and effector T c...

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Veröffentlicht in:	The Journal of clinical investigation 2019-02, Vol.129 (2), p.902-914
Hauptverfasser:	Nalle, Sam C, Zuo, Li, Ong, Ma Lora Drizella M, Singh, Gurminder, Worthylake, Alicia M, Choi, Wangsun, Manresa, Mario Cabrero, Southworth, Anna P, Edelblum, Karen L, Baker, Gregory J, Joseph, Nora E, Savage, Peter A, Turner, Jerrold R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Antigens Apoptosis Biomedical research Biopsy Bone marrow Care and treatment CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell activation Effector cells Enzymatic activity Enzymes Female Gastroenterology Graft versus host disease Graft vs Host Disease - immunology Graft vs Host Disease - pathology Graft vs. host disease Graft-versus-host reaction Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Histochemistry Hypotheses Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestine Leukemia Light Lymphocytes Lymphocytes T Mice Mice, Inbred BALB C Myosin-light-chain kinase Myosin-Light-Chain Kinase - immunology Pathogenesis Permeability Phosphorylation Prevention Propagation Rodents Stem cell transplantation Stem cells Surgery T cells Tight Junctions - immunology Tight Junctions - pathology Transplants & implants
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