The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans
While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysio...
Gespeichert in:
| Veröffentlicht in: | Journal of affective disorders 2018-08, Vol.235, p.52-60 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | |
| container_start_page | 52 |
| container_title | Journal of affective disorders |
| container_volume | 235 |
| creator | Young, Dmitri A Neylan, Thomas C O'Donovan, Aoife Metzler, Thomas Richards, Anne Ross, Jessica A Inslicht, Sabra S |
| description | While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans.
226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively. Fear conditions included no, ambiguous, and high threat conditions. Psychophysiological response measures included electromyogram (EMG), skin conductance response (SCR), and heart rate. The Clinician Administered PTSD Scale (CAPS) and the Trauma History Questionnaire (THQ) were used to assess PTSD status and child abuse history respectively.
Met allele carriers exhibited greater SCR magnitudes in the no and ambiguous threat conditions (p |
| doi_str_mv | 10.1016/j.jad.2018.04.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6354935</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2025310845</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3474-cb4da3acb8654bbc00734df6e62d8f2c0eb3dc500c4d5e7d73e3e1cc6c8f52c93</originalsourceid><addsrcrecordid>eNpVkctu1DAUhi0EokPhAdggL1k04fiaZIPUC22RClRiKEvLsZ3GI08c4qRi3qKP3IQpFazO4vz_d470IfSWQE6AyA-bfKNtToGUOfAcgD9DKyIKllFBiudoNWdEBowWB-hVShsAkFUBL9EBrSSvCkJW6H7dOuy70Q3ajD52ODb45OzrOb7RQcovbjzC1-vvZ0dYdxab1geLdT0lh-don3amjX27Sz6GeOuNDnhwC-fOj7s_jcvrY6x_-4SbqdvzfYc1TnrbB7fcuphCg3_qAd-45YcuvUYvGh2Se_M4D9GP80_r08vs6tvF59Pjq8wwXvDM1Nxqpk1dSsHr2gAUjNtGOklt2VADrmbWCADDrXCFLZhjjhgjTdkIaip2iD7uuf1Ub501rhsHHVQ_-K0edipqr_7fdL5Vt_FOSSZ4xcQMeP8IGOKvyaVRbX0yLgTduTglRYEKRqDkS5Tso2aIKQ2ueTpDQC0m1UbNJtViUgFXs8m58-7f_54af9WxB4tfnNQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2025310845</pqid></control><display><type>article</type><title>The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Young, Dmitri A ; Neylan, Thomas C ; O'Donovan, Aoife ; Metzler, Thomas ; Richards, Anne ; Ross, Jessica A ; Inslicht, Sabra S</creator><creatorcontrib>Young, Dmitri A ; Neylan, Thomas C ; O'Donovan, Aoife ; Metzler, Thomas ; Richards, Anne ; Ross, Jessica A ; Inslicht, Sabra S</creatorcontrib><description>While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans.
226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively. Fear conditions included no, ambiguous, and high threat conditions. Psychophysiological response measures included electromyogram (EMG), skin conductance response (SCR), and heart rate. The Clinician Administered PTSD Scale (CAPS) and the Trauma History Questionnaire (THQ) were used to assess PTSD status and child abuse history respectively.
Met allele carriers exhibited greater SCR magnitudes in the no and ambiguous threat conditions (p < 0.01 and p < 0.05 respectively). Met carriers with PTSD exhibited greater physiological response magnitudes in the ambiguous (SCR, p < 0.001) and high threat conditions (SCR and heart rate, both p ≤ 0.005). Met carrier survivors of child abuse exhibited blunted heart rate magnitudes in the high threat condition (p < 0.01). Met allele carries with PTSD also exhibited greater percent cortisol suppression (p < 0.005).
Limitations included small sample size and the cross-sectional nature of the data.
The Val66met may impact PTSD susceptibility differentially via enhanced threat sensitivity and HPA axis dysregulation. Child abuse may moderate Val66Met's impact on threat reactivity. Future research should explore how neuronal mechanisms might mediate this risk.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2018.04.004</identifier><identifier>PMID: 29649711</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Adaptation, Psychological - physiology ; Adult ; Adult Survivors of Child Abuse - psychology ; Alleles ; Brain-Derived Neurotrophic Factor - genetics ; Cross-Sectional Studies ; Fear - psychology ; Female ; Genetic Predisposition to Disease ; Gulf War ; Humans ; Hydrocortisone - metabolism ; Hypothalamo-Hypophyseal System - physiopathology ; Male ; Middle Aged ; Pituitary-Adrenal System - physiopathology ; Polymorphism, Genetic ; Stress Disorders, Post-Traumatic - genetics ; Stress Disorders, Post-Traumatic - physiopathology ; Stress Disorders, Post-Traumatic - psychology ; United States ; Veterans - psychology</subject><ispartof>Journal of affective disorders, 2018-08, Vol.235, p.52-60</ispartof><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3474-cb4da3acb8654bbc00734df6e62d8f2c0eb3dc500c4d5e7d73e3e1cc6c8f52c93</citedby><cites>FETCH-LOGICAL-c3474-cb4da3acb8654bbc00734df6e62d8f2c0eb3dc500c4d5e7d73e3e1cc6c8f52c93</cites><orcidid>0000-0003-3568-0926 ; 0000-0002-2456-1625</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29649711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, Dmitri A</creatorcontrib><creatorcontrib>Neylan, Thomas C</creatorcontrib><creatorcontrib>O'Donovan, Aoife</creatorcontrib><creatorcontrib>Metzler, Thomas</creatorcontrib><creatorcontrib>Richards, Anne</creatorcontrib><creatorcontrib>Ross, Jessica A</creatorcontrib><creatorcontrib>Inslicht, Sabra S</creatorcontrib><title>The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans.
226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively. Fear conditions included no, ambiguous, and high threat conditions. Psychophysiological response measures included electromyogram (EMG), skin conductance response (SCR), and heart rate. The Clinician Administered PTSD Scale (CAPS) and the Trauma History Questionnaire (THQ) were used to assess PTSD status and child abuse history respectively.
Met allele carriers exhibited greater SCR magnitudes in the no and ambiguous threat conditions (p < 0.01 and p < 0.05 respectively). Met carriers with PTSD exhibited greater physiological response magnitudes in the ambiguous (SCR, p < 0.001) and high threat conditions (SCR and heart rate, both p ≤ 0.005). Met carrier survivors of child abuse exhibited blunted heart rate magnitudes in the high threat condition (p < 0.01). Met allele carries with PTSD also exhibited greater percent cortisol suppression (p < 0.005).
Limitations included small sample size and the cross-sectional nature of the data.
The Val66met may impact PTSD susceptibility differentially via enhanced threat sensitivity and HPA axis dysregulation. Child abuse may moderate Val66Met's impact on threat reactivity. Future research should explore how neuronal mechanisms might mediate this risk.</description><subject>Adaptation, Psychological - physiology</subject><subject>Adult</subject><subject>Adult Survivors of Child Abuse - psychology</subject><subject>Alleles</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Fear - psychology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Gulf War</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Hypothalamo-Hypophyseal System - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pituitary-Adrenal System - physiopathology</subject><subject>Polymorphism, Genetic</subject><subject>Stress Disorders, Post-Traumatic - genetics</subject><subject>Stress Disorders, Post-Traumatic - physiopathology</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>United States</subject><subject>Veterans - psychology</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctu1DAUhi0EokPhAdggL1k04fiaZIPUC22RClRiKEvLsZ3GI08c4qRi3qKP3IQpFazO4vz_d470IfSWQE6AyA-bfKNtToGUOfAcgD9DKyIKllFBiudoNWdEBowWB-hVShsAkFUBL9EBrSSvCkJW6H7dOuy70Q3ajD52ODb45OzrOb7RQcovbjzC1-vvZ0dYdxab1geLdT0lh-don3amjX27Sz6GeOuNDnhwC-fOj7s_jcvrY6x_-4SbqdvzfYc1TnrbB7fcuphCg3_qAd-45YcuvUYvGh2Se_M4D9GP80_r08vs6tvF59Pjq8wwXvDM1Nxqpk1dSsHr2gAUjNtGOklt2VADrmbWCADDrXCFLZhjjhgjTdkIaip2iD7uuf1Ub501rhsHHVQ_-K0edipqr_7fdL5Vt_FOSSZ4xcQMeP8IGOKvyaVRbX0yLgTduTglRYEKRqDkS5Tso2aIKQ2ueTpDQC0m1UbNJtViUgFXs8m58-7f_54af9WxB4tfnNQ</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Young, Dmitri A</creator><creator>Neylan, Thomas C</creator><creator>O'Donovan, Aoife</creator><creator>Metzler, Thomas</creator><creator>Richards, Anne</creator><creator>Ross, Jessica A</creator><creator>Inslicht, Sabra S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3568-0926</orcidid><orcidid>https://orcid.org/0000-0002-2456-1625</orcidid></search><sort><creationdate>20180801</creationdate><title>The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans</title><author>Young, Dmitri A ; Neylan, Thomas C ; O'Donovan, Aoife ; Metzler, Thomas ; Richards, Anne ; Ross, Jessica A ; Inslicht, Sabra S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3474-cb4da3acb8654bbc00734df6e62d8f2c0eb3dc500c4d5e7d73e3e1cc6c8f52c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adaptation, Psychological - physiology</topic><topic>Adult</topic><topic>Adult Survivors of Child Abuse - psychology</topic><topic>Alleles</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cross-Sectional Studies</topic><topic>Fear - psychology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Gulf War</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Polymorphism, Genetic</topic><topic>Stress Disorders, Post-Traumatic - genetics</topic><topic>Stress Disorders, Post-Traumatic - physiopathology</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>United States</topic><topic>Veterans - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, Dmitri A</creatorcontrib><creatorcontrib>Neylan, Thomas C</creatorcontrib><creatorcontrib>O'Donovan, Aoife</creatorcontrib><creatorcontrib>Metzler, Thomas</creatorcontrib><creatorcontrib>Richards, Anne</creatorcontrib><creatorcontrib>Ross, Jessica A</creatorcontrib><creatorcontrib>Inslicht, Sabra S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, Dmitri A</au><au>Neylan, Thomas C</au><au>O'Donovan, Aoife</au><au>Metzler, Thomas</au><au>Richards, Anne</au><au>Ross, Jessica A</au><au>Inslicht, Sabra S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>235</volume><spage>52</spage><epage>60</epage><pages>52-60</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans.
226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively. Fear conditions included no, ambiguous, and high threat conditions. Psychophysiological response measures included electromyogram (EMG), skin conductance response (SCR), and heart rate. The Clinician Administered PTSD Scale (CAPS) and the Trauma History Questionnaire (THQ) were used to assess PTSD status and child abuse history respectively.
Met allele carriers exhibited greater SCR magnitudes in the no and ambiguous threat conditions (p < 0.01 and p < 0.05 respectively). Met carriers with PTSD exhibited greater physiological response magnitudes in the ambiguous (SCR, p < 0.001) and high threat conditions (SCR and heart rate, both p ≤ 0.005). Met carrier survivors of child abuse exhibited blunted heart rate magnitudes in the high threat condition (p < 0.01). Met allele carries with PTSD also exhibited greater percent cortisol suppression (p < 0.005).
Limitations included small sample size and the cross-sectional nature of the data.
The Val66met may impact PTSD susceptibility differentially via enhanced threat sensitivity and HPA axis dysregulation. Child abuse may moderate Val66Met's impact on threat reactivity. Future research should explore how neuronal mechanisms might mediate this risk.</abstract><cop>Netherlands</cop><pmid>29649711</pmid><doi>10.1016/j.jad.2018.04.004</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3568-0926</orcidid><orcidid>https://orcid.org/0000-0002-2456-1625</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0327 |
| ispartof | Journal of affective disorders, 2018-08, Vol.235, p.52-60 |
| issn | 0165-0327 1573-2517 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6354935 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptation, Psychological - physiology Adult Adult Survivors of Child Abuse - psychology Alleles Brain-Derived Neurotrophic Factor - genetics Cross-Sectional Studies Fear - psychology Female Genetic Predisposition to Disease Gulf War Humans Hydrocortisone - metabolism Hypothalamo-Hypophyseal System - physiopathology Male Middle Aged Pituitary-Adrenal System - physiopathology Polymorphism, Genetic Stress Disorders, Post-Traumatic - genetics Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology United States Veterans - psychology |
| title | The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T08%3A08%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20interaction%20of%20BDNF%20Val66Met,%20PTSD,%20and%20child%20abuse%20on%20psychophysiological%20reactivity%20and%20HPA%20axis%20function%20in%20a%20sample%20of%20Gulf%20War%20Veterans&rft.jtitle=Journal%20of%20affective%20disorders&rft.au=Young,%20Dmitri%20A&rft.date=2018-08-01&rft.volume=235&rft.spage=52&rft.epage=60&rft.pages=52-60&rft.issn=0165-0327&rft.eissn=1573-2517&rft_id=info:doi/10.1016/j.jad.2018.04.004&rft_dat=%3Cproquest_pubme%3E2025310845%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2025310845&rft_id=info:pmid/29649711&rfr_iscdi=true |