Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study
ObjectivesThe significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic circulation, featuring hypersegmented morphology, with high oxidative burst and functional plasticity...
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| description | ObjectivesThe significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic circulation, featuring hypersegmented morphology, with high oxidative burst and functional plasticity in inflammatory conditions. The aim of this study was to characterise neutrophil subsets in bronchial lavage (BL) of obstructive airway disease participants (asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis) and healthy controls on the basis of nuclear morphology and to assess the association between neutrophil subsets and the clinical parameters of the obstructive airway disease participants.DesignA cross-sectional exploratory study.SettingJohn Hunter Hospital and Hunter Medical Research Institute, Australia.ParticipantsSeventy-eight adults with obstructive airway disease comprised those with stable asthma (n=39), COPD (n=20) and bronchiectasis (n=19) and 20 healthy controls.Materials and methodsCytospins were prepared and neutrophil subsets were classified based on nuclear morphology into hypersegmented (>4 lobes), normal (2–4 lobes) and banded (1 lobe) neutrophils and enumerated.ResultsNeutrophils from each subset were identified in all participants. Numbers of hypersegmented neutrophils were elevated in participants with airway disease compared with healthy controls (p |
| doi_str_mv | 10.1136/bmjopen-2018-024330 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6352776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2171982839</sourcerecordid><originalsourceid>FETCH-LOGICAL-b472t-a2d764fe7421fa8e3c30f577288c6af1bab5a1a209eb18cbd0be60fdaa4b65f73</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhSMEolXpEyAhS2zYpPgvTsICCVVAkSqxgbVlxzczHiV28E_bvAWPjKczrQorvLmWzneO7tWpqtcEXxDCxHs97_wCrqaYdDWmnDH8rDqlmPNa4KZ5_uR_Up3HuMPl8aZvGvqyOmFY9EK0_Wn1-2pdIETYzOASGKRsuFUrcpBT8MvWThEpZ5BNZcboB6uS9Q7d2rRFAUweimfKboPG7IZ7yTqkTJ6K4R7yOqaQi3QDD-HGRlARPpRkBHfL5INKPqwopmzWV9WLUU0Rzo_zrPr55fOPy6v6-vvXb5efrmvNW5pqRU0r-Agtp2RUHbCB4bFpW9p1g1Aj0Uo3iiiKe9CkG7TBGgQejVJci2Zs2Vn18ZC7ZD2DGcr5QU1yCXZWYZVeWfm34uxWbvyNFKyhbStKwLtjQPC_MsQkZxsHmCblwOcoKWl7LjhnuKBv_0F3PgdXzttTpO9ox_pCsQM1BB9jgPFxGYLlvnR5LF3uS5eH0ovrzdM7Hj0PFRfg4gAU938l_gG4hr5a</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2171982839</pqid></control><display><type>article</type><title>Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study</title><source>BMJ Open Access Journals</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Lokwani, Ravi ; Wark, Peter A B ; Baines, Katherine J ; Barker, Daniel ; Simpson, Jodie L</creator><creatorcontrib>Lokwani, Ravi ; Wark, Peter A B ; Baines, Katherine J ; Barker, Daniel ; Simpson, Jodie L</creatorcontrib><description>ObjectivesThe significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic circulation, featuring hypersegmented morphology, with high oxidative burst and functional plasticity in inflammatory conditions. The aim of this study was to characterise neutrophil subsets in bronchial lavage (BL) of obstructive airway disease participants (asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis) and healthy controls on the basis of nuclear morphology and to assess the association between neutrophil subsets and the clinical parameters of the obstructive airway disease participants.DesignA cross-sectional exploratory study.SettingJohn Hunter Hospital and Hunter Medical Research Institute, Australia.ParticipantsSeventy-eight adults with obstructive airway disease comprised those with stable asthma (n=39), COPD (n=20) and bronchiectasis (n=19) and 20 healthy controls.Materials and methodsCytospins were prepared and neutrophil subsets were classified based on nuclear morphology into hypersegmented (>4 lobes), normal (2–4 lobes) and banded (1 lobe) neutrophils and enumerated.ResultsNeutrophils from each subset were identified in all participants. Numbers of hypersegmented neutrophils were elevated in participants with airway disease compared with healthy controls (p<0.001). Both the number and the proportion of hypersegmented neutrophils were highest in COPD participants (median (Q1–Q3) of 1073.6 (258.8–2742) × 102/mL and 24.5 (14.0–46.5)%, respectively). An increased proportion of hypersegmented neutrophils in airway disease participants was significantly associated with lower forced expiratory volume in 1 s/forced vital capacity per cent (Spearman’s r=−0.322, p=0.004).ConclusionNeutrophil heterogeneity is common in BL and is associated with more severe airflow obstruction in adults with airway disease. Further work is required to elucidate the functional consequences of hypersegmented neutrophils in the pathogenesis of disease.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2018-024330</identifier><identifier>PMID: 30696679</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Aged ; Airway management ; Apoptosis ; Asthma ; Asthma - pathology ; Asthma - physiopathology ; Bronchiectasis - pathology ; Bronchiectasis - physiopathology ; Bronchoalveolar Lavage Fluid ; Case-Control Studies ; Cell Nucleus Shape ; Chronic obstructive pulmonary disease ; Cystic fibrosis ; Cytokines ; Female ; Forced Expiratory Volume ; Hospitals ; Humans ; Infections ; Inflammation ; Male ; Middle Aged ; Neutrophils ; Neutrophils - pathology ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Respiratory Medicine ; TNF inhibitors ; Tumor necrosis factor-TNF ; Vital Capacity</subject><ispartof>BMJ open, 2019-01, Vol.9 (1), p.e024330-e024330</ispartof><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-a2d764fe7421fa8e3c30f577288c6af1bab5a1a209eb18cbd0be60fdaa4b65f73</citedby><cites>FETCH-LOGICAL-b472t-a2d764fe7421fa8e3c30f577288c6af1bab5a1a209eb18cbd0be60fdaa4b65f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/9/1/e024330.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/9/1/e024330.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27526,27527,27901,27902,53766,53768,77344,77375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30696679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lokwani, Ravi</creatorcontrib><creatorcontrib>Wark, Peter A B</creatorcontrib><creatorcontrib>Baines, Katherine J</creatorcontrib><creatorcontrib>Barker, Daniel</creatorcontrib><creatorcontrib>Simpson, Jodie L</creatorcontrib><title>Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesThe significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic circulation, featuring hypersegmented morphology, with high oxidative burst and functional plasticity in inflammatory conditions. The aim of this study was to characterise neutrophil subsets in bronchial lavage (BL) of obstructive airway disease participants (asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis) and healthy controls on the basis of nuclear morphology and to assess the association between neutrophil subsets and the clinical parameters of the obstructive airway disease participants.DesignA cross-sectional exploratory study.SettingJohn Hunter Hospital and Hunter Medical Research Institute, Australia.ParticipantsSeventy-eight adults with obstructive airway disease comprised those with stable asthma (n=39), COPD (n=20) and bronchiectasis (n=19) and 20 healthy controls.Materials and methodsCytospins were prepared and neutrophil subsets were classified based on nuclear morphology into hypersegmented (>4 lobes), normal (2–4 lobes) and banded (1 lobe) neutrophils and enumerated.ResultsNeutrophils from each subset were identified in all participants. Numbers of hypersegmented neutrophils were elevated in participants with airway disease compared with healthy controls (p<0.001). Both the number and the proportion of hypersegmented neutrophils were highest in COPD participants (median (Q1–Q3) of 1073.6 (258.8–2742) × 102/mL and 24.5 (14.0–46.5)%, respectively). An increased proportion of hypersegmented neutrophils in airway disease participants was significantly associated with lower forced expiratory volume in 1 s/forced vital capacity per cent (Spearman’s r=−0.322, p=0.004).ConclusionNeutrophil heterogeneity is common in BL and is associated with more severe airflow obstruction in adults with airway disease. Further work is required to elucidate the functional consequences of hypersegmented neutrophils in the pathogenesis of disease.</description><subject>Aged</subject><subject>Airway management</subject><subject>Apoptosis</subject><subject>Asthma</subject><subject>Asthma - pathology</subject><subject>Asthma - physiopathology</subject><subject>Bronchiectasis - pathology</subject><subject>Bronchiectasis - physiopathology</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Case-Control Studies</subject><subject>Cell Nucleus Shape</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cystic fibrosis</subject><subject>Cytokines</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Neutrophils - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Respiratory Medicine</subject><subject>TNF inhibitors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vital Capacity</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1u1DAUhSMEolXpEyAhS2zYpPgvTsICCVVAkSqxgbVlxzczHiV28E_bvAWPjKczrQorvLmWzneO7tWpqtcEXxDCxHs97_wCrqaYdDWmnDH8rDqlmPNa4KZ5_uR_Up3HuMPl8aZvGvqyOmFY9EK0_Wn1-2pdIETYzOASGKRsuFUrcpBT8MvWThEpZ5BNZcboB6uS9Q7d2rRFAUweimfKboPG7IZ7yTqkTJ6K4R7yOqaQi3QDD-HGRlARPpRkBHfL5INKPqwopmzWV9WLUU0Rzo_zrPr55fOPy6v6-vvXb5efrmvNW5pqRU0r-Agtp2RUHbCB4bFpW9p1g1Aj0Uo3iiiKe9CkG7TBGgQejVJci2Zs2Vn18ZC7ZD2DGcr5QU1yCXZWYZVeWfm34uxWbvyNFKyhbStKwLtjQPC_MsQkZxsHmCblwOcoKWl7LjhnuKBv_0F3PgdXzttTpO9ox_pCsQM1BB9jgPFxGYLlvnR5LF3uS5eH0ovrzdM7Hj0PFRfg4gAU938l_gG4hr5a</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Lokwani, Ravi</creator><creator>Wark, Peter A B</creator><creator>Baines, Katherine J</creator><creator>Barker, Daniel</creator><creator>Simpson, Jodie L</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study</title><author>Lokwani, Ravi ; Wark, Peter A B ; Baines, Katherine J ; Barker, Daniel ; Simpson, Jodie L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-a2d764fe7421fa8e3c30f577288c6af1bab5a1a209eb18cbd0be60fdaa4b65f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Airway management</topic><topic>Apoptosis</topic><topic>Asthma</topic><topic>Asthma - pathology</topic><topic>Asthma - physiopathology</topic><topic>Bronchiectasis - pathology</topic><topic>Bronchiectasis - physiopathology</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Case-Control Studies</topic><topic>Cell Nucleus Shape</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cystic fibrosis</topic><topic>Cytokines</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Neutrophils - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Respiratory Medicine</topic><topic>TNF inhibitors</topic><topic>Tumor necrosis factor-TNF</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lokwani, Ravi</creatorcontrib><creatorcontrib>Wark, Peter A B</creatorcontrib><creatorcontrib>Baines, Katherine J</creatorcontrib><creatorcontrib>Barker, Daniel</creatorcontrib><creatorcontrib>Simpson, Jodie L</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lokwani, Ravi</au><au>Wark, Peter A B</au><au>Baines, Katherine J</au><au>Barker, Daniel</au><au>Simpson, Jodie L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>e024330</spage><epage>e024330</epage><pages>e024330-e024330</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>ObjectivesThe significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic circulation, featuring hypersegmented morphology, with high oxidative burst and functional plasticity in inflammatory conditions. The aim of this study was to characterise neutrophil subsets in bronchial lavage (BL) of obstructive airway disease participants (asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis) and healthy controls on the basis of nuclear morphology and to assess the association between neutrophil subsets and the clinical parameters of the obstructive airway disease participants.DesignA cross-sectional exploratory study.SettingJohn Hunter Hospital and Hunter Medical Research Institute, Australia.ParticipantsSeventy-eight adults with obstructive airway disease comprised those with stable asthma (n=39), COPD (n=20) and bronchiectasis (n=19) and 20 healthy controls.Materials and methodsCytospins were prepared and neutrophil subsets were classified based on nuclear morphology into hypersegmented (>4 lobes), normal (2–4 lobes) and banded (1 lobe) neutrophils and enumerated.ResultsNeutrophils from each subset were identified in all participants. Numbers of hypersegmented neutrophils were elevated in participants with airway disease compared with healthy controls (p<0.001). Both the number and the proportion of hypersegmented neutrophils were highest in COPD participants (median (Q1–Q3) of 1073.6 (258.8–2742) × 102/mL and 24.5 (14.0–46.5)%, respectively). An increased proportion of hypersegmented neutrophils in airway disease participants was significantly associated with lower forced expiratory volume in 1 s/forced vital capacity per cent (Spearman’s r=−0.322, p=0.004).ConclusionNeutrophil heterogeneity is common in BL and is associated with more severe airflow obstruction in adults with airway disease. Further work is required to elucidate the functional consequences of hypersegmented neutrophils in the pathogenesis of disease.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30696679</pmid><doi>10.1136/bmjopen-2018-024330</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Airway management Apoptosis Asthma Asthma - pathology Asthma - physiopathology Bronchiectasis - pathology Bronchiectasis - physiopathology Bronchoalveolar Lavage Fluid Case-Control Studies Cell Nucleus Shape Chronic obstructive pulmonary disease Cystic fibrosis Cytokines Female Forced Expiratory Volume Hospitals Humans Infections Inflammation Male Middle Aged Neutrophils Neutrophils - pathology Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory Medicine TNF inhibitors Tumor necrosis factor-TNF Vital Capacity |
| title | Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study |
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