Aging differentially modulates the Wnt pro‐survival signalling pathways in vascular smooth muscle cells

We previously reported pro‐survival effects of Wnt3a and Wnt5a proteins in vascular smooth muscle cells (VSMCs). Wnt5a achieved this through induction of Wnt1‐inducible signalling pathway protein‐1 (WISP‐1) consequent to β‐catenin/CREB‐dependent, TCF‐independent, signalling. However, we found that a...

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Veröffentlicht in:	Aging cell 2019-02, Vol.18 (1), p.e12844-n/a
Hauptverfasser:	Brown, Bethan A., Connolly, Georgia M., Mill, Carina E. J., Williams, Helen, Angelini, Gianni D., Johnson, Jason L., George, Sarah J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aging Animals apoptosis Apoptosis - drug effects Arteriosclerosis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology beta Catenin - metabolism Catenin CCN Intercellular Signaling Proteins - metabolism Cell Survival - drug effects Cellular Senescence - drug effects Child Coronary artery Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Frizzled Receptors - metabolism Gene expression Gene Expression Regulation - drug effects Geriatrics Humans Hydrogen Peroxide - toxicity Macrophages Mice, Inbred C57BL Middle Aged Models, Biological Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Nuclear transport Original Paper Original Papers oxidative stress Phosphorylation Protein Binding - drug effects Proteins Repressor Proteins - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Smooth muscle Survival factor TCF Transcription Factors - metabolism Up-Regulation - drug effects vascular smooth muscle cell Wnt Wnt protein Wnt Signaling Pathway - drug effects Wnt-5a Protein - metabolism Wnt3A Protein - metabolism Young Adult
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