Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients

Immunomodulatory drugs (IMIDs) are very effective in the treatment of multiple myeloma (MM). The description of their cereblon-mediated mechanism of action was a hallmark in MM research. Although the importance of IMID-induced degradation of cereblon-binding proteins is well described in vitro, the...

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Veröffentlicht in:	Blood cancer journal (New York) 2019-01, Vol.9 (2), p.13-13, Article 13
Hauptverfasser:	Kriegsmann, Katharina, Baertsch, Marc-Andrea, Awwad, Mohamed H. S., Merz, Maximilian, Hose, Dirk, Seckinger, Anja, Jauch, Anna, Becker, Natalia, Benner, Axel, Raab, Marc S., Hillengass, Jens, Bertsch, Uta, Dürig, Jan, Salwender, Hans Jürgen, Hänel, Mathias, Fenk, Roland, Munder, Markus, Weisel, Katja, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Hundemer, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/32 631/67/1059/2325 692/699/1541/1990/804 Adaptor Proteins, Signal Transducing - metabolism Adult Aged Biomarkers, Tumor Biomedical and Life Sciences Biomedicine Cancer Research Carrier Proteins - genetics Carrier Proteins - metabolism Cytogenetic Analysis Female Gene Expression Hematology Humans Immunophenotyping Male Middle Aged Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - metabolism Neoplasm Staging Oncology Polyploidy Protein Binding Proteins
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