Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells

The mevalonate pathway has emerged as a promising target for several solid tumors. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of this pathway, and are commonly used to treat patients with hypercholesterolemia. Pleiotropic antitumor mechan...

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Veröffentlicht in:	Cell death & disease 2019-01, Vol.10 (2), p.91-91, Article 91
Hauptverfasser:	Göbel, Andy, Breining, Dorit, Rauner, Martina, Hofbauer, Lorenz C., Rachner, Tilman D.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 38/109 38/77 38/89 38/90 631/67/1347 631/80/82 Antibodies Antitumor activity Apoptosis Atorvastatin Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - genetics Cell Biology Cell Culture Cell Line, Tumor Dipyridamole DNA fragmentation Drug Resistance, Neoplasm Enzyme Induction Female Gene Expression Humans Hydroxymethylglutaryl CoA Reductases - biosynthesis Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Hydroxymethylglutaryl-CoA reductase Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypercholesterolemia Immunology Life Sciences MCF-7 Cells Mevalonate pathway Mevalonic acid Ribose Simvastatin Solid tumors Statins Sterol regulatory element-binding protein Transcription Tumor cell lines
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