CXXC5: A novel regulator and coordinator of TGF‐β, BMP and Wnt signaling

CXXC5 is a member of the CXXC‐type zinc‐finger protein family. Proteins in this family play a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene promoters through their characteristic CXXC domain. CXXC5 is a short protein (322 amino acids in length) that does not ha...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2019-02, Vol.23 (2), p.740-749
Hauptverfasser:	Xiong, Xiangyang, Tu, Shuo, Wang, Jianbin, Luo, Shiwen, Yan, Xiaohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis beta Catenin - genetics beta Catenin - metabolism Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Carcinogenesis - genetics Carcinogenesis - metabolism Carcinogenesis - pathology Cell proliferation CpG islands CXXC domain CXXC5 Deoxyribonucleic acid DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryogenesis Embryonic growth stage Epigenesis, Genetic Epigenetics Homeostasis Humans Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology p53 Protein Protein Binding Protein Domains Protein interaction Proteins Review Reviews Signal Transduction signaling coordinator transcription factor Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transduction Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism tumour suppressor Wnt protein Wnt3A Protein - genetics Wnt3A Protein - metabolism Zinc Zinc finger proteins
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