Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer

TIGIT is an inhibitory immune checkpoint receptor and a putative target for novel immune therapies. Here, we analysed two different types of tissue microarrays of healthy lymphatic and various inflamed tissues, colorectal and lung cancers, as well as >1700 tumour samples from 86 different tumour...

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Veröffentlicht in:	Disease markers 2019-01, Vol.2019, p.5160565-13
Hauptverfasser:	Blessin, Niclas C., Simon, Ronald, Kluth, Martina, Fischer, Kristine, Hube-Magg, Claudia, Li, Wenchao, Makrypidi-Fraune, Georgia, Wellge, Björn, Mandelkow, Tim, Debatin, Nicolaus F., Höflmayer, Doris, Lennartz, Maximilian, Sauter, Guido, Izbicki, Jakob R., Minner, Sarah, Büscheck, Franziska, Uhlig, Ria, Dum, David, Krech, Till, Luebke, Andreas M., Wittmer, Corinna, Jacobsen, Frank, Burandt, Eike-Christian, Steurer, Stefan, Wilczak, Waldemar, Hinsch, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Cancer Cancer therapies CD11c antigen CD20 antigen CD4 antigen CD8 antigen Compartments Cytotoxicity Dendritic cells Fluorescence Foxp3 protein Helper cells Immune checkpoint Immunoglobulins Immunohistochemistry Immunology Immunoregulation Immunotherapy Inflammatory diseases Lung cancer Lymphatic system Lymphocytes Lymphocytes B Lymphocytes T Macrophages Medical research Melanoma Metastasis Microenvironments PD-1 protein Proteins Sarcoidosis T cell receptors Thyroiditis Tissues Tonsil Tumors
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