Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium

Advances in genomic technologies have led to a wealth of information identifying genetic polymorphisms in membrane transporters, specifically how these polymorphisms affect drug disposition and response. This review describes the current perspective of the International Transporter Consortium (ITC)...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2018-11, Vol.104 (5), p.803-817
Hauptverfasser:	Yee, Sook Wah, Brackman, Deanna J., Ennis, Elizabeth A., Sugiyama, Yuichi, Kamdem, Landry K., Blanchard, Rebecca, Galetin, Aleksandra, Zhang, Lei, Giacomini, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Interactions Drug-Related Side Effects and Adverse Reactions - genetics Drug-Related Side Effects and Adverse Reactions - metabolism Genotype Humans Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Pharmaceutical Preparations - metabolism Pharmacogenomic Variants Pharmacokinetics Phenotype Polymorphism, Genetic Risk Assessment
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