The effect of apolipoprotein E polymorphism on serum metabolome – a population-based 10-year follow-up study

Apolipoprotein E (apoE) is the key regulator of plasma lipids, mediating altered functionalities in lipoprotein metabolism – affecting the risk of coronary artery (CAD) and Alzheimer’s diseases, as well as longevity. Searching pathways influenced by apoE prior to adverse manifestations, we utilized...

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Veröffentlicht in:	Scientific reports 2019-01, Vol.9 (1), p.458-458, Article 458
Hauptverfasser:	Karjalainen, Juho-Pekka, Mononen, Nina, Hutri-Kähönen, Nina, Lehtimäki, Miikael, Juonala, Markus, Ala-Korpela, Mika, Kähönen, Mika, Raitakari, Olli, Lehtimäki, Terho
Format:	Artikel
Sprache:	eng
Schlagworte:	140/131 45/22 45/23 45/77 631/208/205 631/443/592/2727 692/4019/592/75 692/4019/592/75/2099 692/53/2423 Adult Alleles Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Biomarkers Biomarkers - blood Cholesterol Coronary artery Cross-Sectional Studies Diabetes mellitus Disease Susceptibility Female Gene Frequency Genotype Health risks Humanities and Social Sciences Humans Isoleucine Lipid metabolism Lipids Lipoproteins Longitudinal Studies Low density lipoprotein Male Metabolites Metabolome Metabolomics - methods Mortality Mortality risk multidisciplinary Phospholipids Polymorphism Polymorphism, Genetic Population studies Population-based studies Science Science (multidisciplinary) Triglycerides Young Adult
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