Impaired activation of lesional CD8+ T-cells is associated with enhanced expression of Programmed Death-1 in Indian Post Kala-azar Dermal Leishmaniasis

Post Kala-azar dermal leishmaniasis (PKDL), caused by Leishmania donovani is the dermal sequel of Visceral Leishmaniasis and importantly, is the proposed disease reservoir. The survival of Leishmania parasites within monocytes/macrophages hinges on its ability to effectively nullify immune activatio...

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Veröffentlicht in:	Scientific reports 2019-01, Vol.9 (1), p.762-762, Article 762
Hauptverfasser:	Mukherjee, Shibabrata, Sengupta, Ritika, Mukhopadhyay, Debanjan, Braun, Claudia, Mitra, Sneha, Roy, Susmita, Kanti Das, Nilay, Chatterjee, Uttara, von Stebut, Esther, Chatterjee, Mitali
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 13/51 14/63 38/77 631/250/127/1213 631/250/1619/554/1834 631/250/2161 631/250/98 692/699/255/1715 Animal models Apoptosis CCL17 protein CD4 antigen CD8 antigen Cell activation Humanities and Social Sciences Immune response Immunotherapy Inactivation Interleukin 10 Interleukin 5 Lymphocytes T Macrophages Monocytes multidisciplinary Parasites Parasitic diseases PD-1 protein Perforin Science Science (multidisciplinary) Skin Vector-borne diseases Visceral leishmaniasis ZAP-70 protein
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