Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches

This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches to creating catalytic activity and classification of noncomputational methods into rational and combinatorial classes. The...

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Veröffentlicht in:Annual review of biomedical engineering 2016-07, Vol.18 (1), p.311-328
Hauptverfasser: Maeda, Yoshiaki, Makhlynets, Olga V, Matsui, Hiroshi, Korendovych, Ivan V
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container_title Annual review of biomedical engineering
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creator Maeda, Yoshiaki
Makhlynets, Olga V
Matsui, Hiroshi
Korendovych, Ivan V
description This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches to creating catalytic activity and classification of noncomputational methods into rational and combinatorial classes. The section on rational design covers recent progress in the development of short peptides and oligomeric peptide assemblies for various natural and unnatural reactions. The section on combinatorial design describes recent advances in the discovery of catalytic peptides. We present the future prospects of these and other new approaches in a broader context, including implications for functional material design.
doi_str_mv 10.1146/annurev-bioeng-111215-024421
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subjects Catalysis
Combinatorial Chemistry Techniques - methods
Drug Design
Drug Evaluation, Preclinical - methods
Enzymes - chemical synthesis
metalloenzymes
Peptides - chemical synthesis
phage display
protein design
Protein Engineering - methods
supramolecular assemblies
title Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches
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