PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

The PERK arm of the unfolded protein response (UPR) regulates cellular proteostasis and survival in response to endoplasmic reticulum (ER) stress. However, the impact of PERK signaling on extracellular proteostasis is poorly understood. We define how PERK signaling influences extracellular proteosta...

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Veröffentlicht in:	Scientific reports 2019-01, Vol.9 (1), p.410, Article 410
Hauptverfasser:	Romine, Isabelle C., Wiseman, R. Luke
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/470/1463 631/80/86/2366 Aging Amyloid Neuropathies, Familial - metabolism Amyloid Neuropathies, Familial - pathology Amyloidogenesis eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress HEK293 Cells Humanities and Social Sciences Humans multidisciplinary Prealbumin - metabolism Protein folding Proteins Proteostasis Science Science (multidisciplinary) Secretion Thapsigargin Thapsigargin - adverse effects Thapsigargin - pharmacology Transthyretin
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