Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins

DNA replication commences at eukaryotic replication origins following assembly and activation of bidirectional CMG helicases. Once activated, CMG unwinds the parental DNA duplex and DNA polymerase α-primase initiates synthesis on both template strands. By utilizing an origin-dependent replication sy...

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Veröffentlicht in:	Molecular cell 2019-01, Vol.73 (2), p.199-211.e10
Hauptverfasser:	Aria, Valentina, Yeeles, Joseph T.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	CMG helicase DNA DNA polymerase DNA replication DNA-directed DNA polymerase leading-strand synthesis primase priming proteins replication fork replication origin replisome yeasts
Online-Zugang:	Volltext
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