Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke

Recent evidence suggests that blood-brain barrier (BBB) recovery and reestablishment of BBB impermeability after stroke is incomplete. This could influence stroke recovery, increase the risk of repeat stroke, and be a solid substrate for developing vascular dementia. Although accumulating evidence h...

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Veröffentlicht in:	The Journal of neuroscience 2019-01, Vol.39 (4), p.743-757
Hauptverfasser:	Sladojevic, Nikola, Stamatovic, Svetlana M, Johnson, Allison M, Choi, Jennifer, Hu, Anna, Dithmer, Sophie, Blasig, Ingolf E, Keep, Richard F, Andjelkovic, Anuska V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barriers Blood vessels Blood-brain barrier Blood-Brain Barrier - pathology Brain Brain Ischemia - pathology Cell membranes Claudin-1 - genetics Claudin-5 - biosynthesis Claudin-5 - genetics Dementia disorders Destabilization Down-Regulation - genetics Endothelial cells Endothelial Cells - pathology Energy recovery Energy transfer Female Fluorescence Fluorescence recovery after photobleaching Fluorescence resonance energy transfer Health risks Humans Infarction, Middle Cerebral Artery - genetics Infarction, Middle Cerebral Artery - pathology Inflammation Inflammation - pathology Leakage Male Mice Morphology mRNA Permeability Phenotypes Photobleaching Proteins Recovery of function Stroke Stroke - genetics Stroke - pathology Substrates Tight Junctions - pathology Vascular dementia Zonula occludens-1 protein Zonula Occludens-1 Protein - biosynthesis Zonula Occludens-1 Protein - genetics
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