Dynamic Contrast-Enhanced MRI of OATP Dysfunction in Diabetes

Diabetes is associated with hepatic metabolic dysfunction predisposing patients to drug-induced liver injury. Mouse models of type 2 diabetes (T2D) have dramatically reduced expression of organic anion transporting polypeptide (OATP)1A1, a transporter expressed in hepatocytes and in the kidneys. The...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2019-02, Vol.68 (2), p.271-280
Hauptverfasser:	Shuboni-Mulligan, Dorela D, Parys, Maciej, Blanco-Fernandez, Barbara, Mallett, Christiane L, Schnegelberger, Regina, Takada, Marilia, Chakravarty, Shatadru, Hagenbuch, Bruno, Shapiro, Erik M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bile Bile acids Contrast Media - chemistry Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Drug therapy Gadolinium Gadolinium DTPA Gene expression Hepatocytes Kidneys Liver Liver-Specific Organic Anion Transporter 1 - metabolism Magnetic resonance imaging Magnetic Resonance Imaging - methods Mice Mice, Knockout mRNA Organic Anion Transporters - metabolism Organic anion transporting polypeptide Organic Cation Transport Proteins - metabolism Technological Advances
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