Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease
Aim. To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no...
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| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-9 |
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| creator | Kemény-Beke, Ádám Szodoray, Peter Gesztelyi, Rudolf Biro, Attila Remenyik, Judit Zold, Eva Rentka, Aniko Czompa, Levente Barta, Zsolt Zsuga, Judit |
| description | Aim. To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results. The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications. |
| doi_str_mv | 10.1155/2019/8310583 |
| format | Article |
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To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results. The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/8310583</identifier><identifier>PMID: 30729131</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Cataracts ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - drug therapy ; Colitis, Ulcerative - physiopathology ; Complications ; Crohn's disease ; Cross-Sectional Studies ; Disease control ; Dry Eye Syndromes - complications ; Dry Eye Syndromes - drug therapy ; Dry Eye Syndromes - physiopathology ; Eye ; Eye (anatomy) ; Eye diseases ; Female ; Gastroenterology ; Humans ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory Bowel Diseases - physiopathology ; Intestine ; Lubricant Eye Drops - administration & dosage ; Male ; Middle Aged ; Parameters ; Patients ; Prospective Studies ; Studies ; Subgroups ; Surveys and Questionnaires ; Tears ; Tumor necrosis factor-α ; Ulcerative colitis ; Vitamin deficiency</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-9</ispartof><rights>Copyright © 2019 Zsolt Barta et al.</rights><rights>Copyright © 2019 Zsolt Barta et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Zsolt Barta et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5d2f2e84667d5e5c9f836673268eecdaa789f9481d8f52b9a8669fdbdb601de3</citedby><cites>FETCH-LOGICAL-c471t-5d2f2e84667d5e5c9f836673268eecdaa789f9481d8f52b9a8669fdbdb601de3</cites><orcidid>0000-0003-1321-0907 ; 0000-0001-8997-6541 ; 0000-0001-7911-055X ; 0000-0002-8200-6937</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341274/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341274/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30729131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ramana, Kota V.</contributor><contributor>Kota V Ramana</contributor><creatorcontrib>Kemény-Beke, Ádám</creatorcontrib><creatorcontrib>Szodoray, Peter</creatorcontrib><creatorcontrib>Gesztelyi, Rudolf</creatorcontrib><creatorcontrib>Biro, Attila</creatorcontrib><creatorcontrib>Remenyik, Judit</creatorcontrib><creatorcontrib>Zold, Eva</creatorcontrib><creatorcontrib>Rentka, Aniko</creatorcontrib><creatorcontrib>Czompa, Levente</creatorcontrib><creatorcontrib>Barta, Zsolt</creatorcontrib><creatorcontrib>Zsuga, Judit</creatorcontrib><title>Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aim. To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results. The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.</description><subject>Adult</subject><subject>Cataracts</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Complications</subject><subject>Crohn's disease</subject><subject>Cross-Sectional Studies</subject><subject>Disease control</subject><subject>Dry Eye Syndromes - complications</subject><subject>Dry Eye Syndromes - drug therapy</subject><subject>Dry Eye Syndromes - physiopathology</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Eye diseases</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - 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To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results. The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30729131</pmid><doi>10.1155/2019/8310583</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1321-0907</orcidid><orcidid>https://orcid.org/0000-0001-8997-6541</orcidid><orcidid>https://orcid.org/0000-0001-7911-055X</orcidid><orcidid>https://orcid.org/0000-0002-8200-6937</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Cataracts Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Colitis, Ulcerative - physiopathology Complications Crohn's disease Cross-Sectional Studies Disease control Dry Eye Syndromes - complications Dry Eye Syndromes - drug therapy Dry Eye Syndromes - physiopathology Eye Eye (anatomy) Eye diseases Female Gastroenterology Humans Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - physiopathology Intestine Lubricant Eye Drops - administration & dosage Male Middle Aged Parameters Patients Prospective Studies Studies Subgroups Surveys and Questionnaires Tears Tumor necrosis factor-α Ulcerative colitis Vitamin deficiency |
| title | Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease |
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