Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice

Abstract Aims The effectiveness of cell-based treatments for regenerative myocardial therapy is limited by low rates of cell engraftment. Y-27632 inhibits Rho-associated protein kinase (ROCK), which regulates the cytoskeletal changes associated with cell adhesion, and has been used to protect cultu...

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Veröffentlicht in:	Cardiovascular research 2019-02, Vol.115 (2), p.343-356
Hauptverfasser:	Zhao, Meng, Fan, Chengming, Ernst, Patrick J, Tang, Yawen, Zhu, Hanxi, Mattapally, Saidulu, Oduk, Yasin, Borovjagin, Anton V, Zhou, Lufang, Zhang, Jianyi, Zhu, Wuqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals Apoptosis - drug effects Cell Adhesion - drug effects Cell Differentiation Cell Survival - drug effects Cells, Cultured Disease Models, Animal Graft Survival - drug effects Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - enzymology Induced Pluripotent Stem Cells - transplantation Mice, Inbred NOD Mice, SCID Myocardial Contraction - drug effects Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - surgery Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - transplantation Original Phenotype Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Recovery of Function rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Time Factors
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