Hallmarks of cardiac regeneration

Despite substantial advances, bona fide regeneration of the damaged human heart is still an unmet ambition. By extracting our current knowledge from developmental biology, animal models of heart regeneration, and clinical observations, we propose five hallmarks of cardiac regeneration and suggest a...

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Veröffentlicht in:	Nature reviews cardiology 2018-10, Vol.15 (10), p.579-580
Hauptverfasser:	Bertero, Alessandro, Murry, Charles E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/51/1844 631/61/490 692/4019/592/2725 692/4019/592/2726 692/4019/592/75/2/1674 Animals Bioengineering Cardiac Imaging Cardiac patients Cardiac Surgery Cardiology Cardiovascular diseases Clinical trials Comment Fibrosis Heart Heart cells Heart diseases Heart Diseases - immunology Heart Diseases - pathology Heart Diseases - physiopathology Heart Diseases - therapy Humans Medicine Medicine & Public Health Muscle Development Myocardium - immunology Myocardium - metabolism Myocardium - pathology Neovascularization, Physiologic Recovery of Function Regeneration (Biology) Regenerative Medicine - methods Stem cells Tissue engineering Treatment Outcome Universities and colleges Ventricular Remodeling
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Beschreibung
Zusammenfassung:	Despite substantial advances, bona fide regeneration of the damaged human heart is still an unmet ambition. By extracting our current knowledge from developmental biology, animal models of heart regeneration, and clinical observations, we propose five hallmarks of cardiac regeneration and suggest a holistic approach to reconstituting human heart function.
ISSN:	1759-5002 1759-5010
DOI:	10.1038/s41569-018-0079-8