Does hyperthermic preconditioning affect the rate of surgical site infection rate and inflammatory reaction in colorectal cancer patients? A prospective randomized clinical trial
Hyperthermic preconditioning has been shown to protect against different insults in experimental studies. However, clinical studies assessing its effects remain limited. The aim of this study was to investigate the effects of hyperthermic preconditioning on the rate of surgical site infection and in...
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| Veröffentlicht in: | Turkish journal of surgery 2018-12, Vol.34 (4), p.282-285 |
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| container_title | Turkish journal of surgery |
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| creator | Attaallah, Wafi Şen, Leyla Semiha Aktan, Ahmet Özdemir Ekşioğlu, Emel Demiralp Eti, Zeynep Güler, Sertaç Ata Cingi, Asım |
| description | Hyperthermic preconditioning has been shown to protect against different insults in experimental studies. However, clinical studies assessing its effects remain limited. The aim of this study was to investigate the effects of hyperthermic preconditioning on the rate of surgical site infection and inflammatory reaction in patients undergoing elective colorectal cancer surgery.
Patients with colorectal cancer, scheduled to undergo elective surgery were enrolled in this prospective randomized study. Patients were randomly assigned to either the hyperthermic preconditioning group or control group. Postoperative superficial and deep surgical site infection were recorded. Blood samples were collected from all the patients in the hyperthermic preconditioning group prior to the application of hyperthermia 12 h before surgery, immediately prior to surgery, and 4 h and 24 h postoperatively. For the control group, blood samples were obtained within the same periods without the application of hyperthermia. Levels of interleukin-1, IL-6, and tumor necrosis factor-α were measured from blood samples.
Twenty patients were randomized to the hyperthermic preconditioning group and 21 to the control group. No significant difference was found in deep or superficial surgical site infection between the groups. No significant difference in the tumor necrosis factor-α, interleukin-1, and IL-6 levels was found in serum samples collected before hyperthermia, during the operation, and postoperatively.
This study showed that hyperthermic preconditioning has no effect on the surgical site infection and cytokine response in patients undergoing elective surgical intervention for colorectal cancer. |
| doi_str_mv | 10.5152/turkjsurg.2018.3981 |
| format | Article |
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Patients with colorectal cancer, scheduled to undergo elective surgery were enrolled in this prospective randomized study. Patients were randomly assigned to either the hyperthermic preconditioning group or control group. Postoperative superficial and deep surgical site infection were recorded. Blood samples were collected from all the patients in the hyperthermic preconditioning group prior to the application of hyperthermia 12 h before surgery, immediately prior to surgery, and 4 h and 24 h postoperatively. For the control group, blood samples were obtained within the same periods without the application of hyperthermia. Levels of interleukin-1, IL-6, and tumor necrosis factor-α were measured from blood samples.
Twenty patients were randomized to the hyperthermic preconditioning group and 21 to the control group. No significant difference was found in deep or superficial surgical site infection between the groups. No significant difference in the tumor necrosis factor-α, interleukin-1, and IL-6 levels was found in serum samples collected before hyperthermia, during the operation, and postoperatively.
This study showed that hyperthermic preconditioning has no effect on the surgical site infection and cytokine response in patients undergoing elective surgical intervention for colorectal cancer.</description><identifier>ISSN: 2564-6850</identifier><identifier>EISSN: 2564-7032</identifier><identifier>DOI: 10.5152/turkjsurg.2018.3981</identifier><identifier>PMID: 30248285</identifier><language>eng</language><publisher>Turkey: Turkish Surgical Association</publisher><subject>Blood transfusions ; Cancer therapies ; Colorectal cancer ; Cytokines ; Diabetes ; Fever ; Heat ; Hyperthermia ; Infections ; Ischemia ; Original ; Patients ; Sepsis ; Studies ; Surgery ; Surgical site infections ; Tumor necrosis factor-TNF</subject><ispartof>Turkish journal of surgery, 2018-12, Vol.34 (4), p.282-285</ispartof><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2018 by the Turkish Surgical Association 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340656/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340656/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30248285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attaallah, Wafi</creatorcontrib><creatorcontrib>Şen, Leyla Semiha</creatorcontrib><creatorcontrib>Aktan, Ahmet Özdemir</creatorcontrib><creatorcontrib>Ekşioğlu, Emel Demiralp</creatorcontrib><creatorcontrib>Eti, Zeynep</creatorcontrib><creatorcontrib>Güler, Sertaç Ata</creatorcontrib><creatorcontrib>Cingi, Asım</creatorcontrib><creatorcontrib>Department of Immunology, Marmara University School of Medicine, Istanbul, Turkey</creatorcontrib><creatorcontrib>Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey</creatorcontrib><creatorcontrib>Department of Anesthesia, Marmara University School of Medicine, Istanbul, Turkey</creatorcontrib><title>Does hyperthermic preconditioning affect the rate of surgical site infection rate and inflammatory reaction in colorectal cancer patients? A prospective randomized clinical trial</title><title>Turkish journal of surgery</title><addtitle>Turk J Surg</addtitle><description>Hyperthermic preconditioning has been shown to protect against different insults in experimental studies. However, clinical studies assessing its effects remain limited. The aim of this study was to investigate the effects of hyperthermic preconditioning on the rate of surgical site infection and inflammatory reaction in patients undergoing elective colorectal cancer surgery.
Patients with colorectal cancer, scheduled to undergo elective surgery were enrolled in this prospective randomized study. Patients were randomly assigned to either the hyperthermic preconditioning group or control group. Postoperative superficial and deep surgical site infection were recorded. Blood samples were collected from all the patients in the hyperthermic preconditioning group prior to the application of hyperthermia 12 h before surgery, immediately prior to surgery, and 4 h and 24 h postoperatively. For the control group, blood samples were obtained within the same periods without the application of hyperthermia. Levels of interleukin-1, IL-6, and tumor necrosis factor-α were measured from blood samples.
Twenty patients were randomized to the hyperthermic preconditioning group and 21 to the control group. No significant difference was found in deep or superficial surgical site infection between the groups. No significant difference in the tumor necrosis factor-α, interleukin-1, and IL-6 levels was found in serum samples collected before hyperthermia, during the operation, and postoperatively.
This study showed that hyperthermic preconditioning has no effect on the surgical site infection and cytokine response in patients undergoing elective surgical intervention for colorectal cancer.</description><subject>Blood transfusions</subject><subject>Cancer therapies</subject><subject>Colorectal cancer</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Fever</subject><subject>Heat</subject><subject>Hyperthermia</subject><subject>Infections</subject><subject>Ischemia</subject><subject>Original</subject><subject>Patients</subject><subject>Sepsis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Surgical site infections</subject><subject>Tumor necrosis factor-TNF</subject><issn>2564-6850</issn><issn>2564-7032</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUduKFDEUDKK4y7pfIEjA5xlz7-4XZdn1Bgu-6HM4nU5msnYnbZJeGD_LLzTtjIM-JZyqU1WHQuglJVtJJXtTlvT9IS9pt2WEtlvetfQJumRSiU1DOHt6-qtWkgt0nbPviZREUqXkc3TBCRMta-Ul-nUXbcb7w2xT2ds0eYPnZE0Mgy8-Bh92GJyzpuAK4wTF4ujwauwNjDj7OvBhJVT2EYcwrKMRpglKTAecLBxhH7CJY6z6pe4aCMYmPEPxNpT8Dt9U65jnVetx9QpDnPxPO2Az-vDHriQP4wv0zMGY7fXpvULfPrz_evtpc__l4-fbm_uNEZKUDZOUCOmkg46y1jLTqq5TvWg66JWyA3DeU2EISMYENIMD14m-YY2jPfQC-BV6e9Sdl36yg6khE4x6Tn6CdNARvP4fCX6vd_FRKy6IkqoKvD4JpPhjsbnoh7ikUDNrxlrRkJZyUln8yDL1-JysOztQoteu9blrvXat167r1qt_w513_jbLfwMmva7O</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Attaallah, Wafi</creator><creator>Şen, Leyla Semiha</creator><creator>Aktan, Ahmet Özdemir</creator><creator>Ekşioğlu, Emel Demiralp</creator><creator>Eti, Zeynep</creator><creator>Güler, Sertaç Ata</creator><creator>Cingi, Asım</creator><general>Turkish Surgical Association</general><general>Turkish Journal of Surgery</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20181201</creationdate><title>Does hyperthermic preconditioning affect the rate of surgical site infection rate and inflammatory reaction in colorectal cancer patients? A prospective randomized clinical trial</title><author>Attaallah, Wafi ; Şen, Leyla Semiha ; Aktan, Ahmet Özdemir ; Ekşioğlu, Emel Demiralp ; Eti, Zeynep ; Güler, Sertaç Ata ; Cingi, Asım</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-251045f5fa9128e2c86996b479ab66eda33b14c0a5224a7dfaf94b727f1bab4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blood transfusions</topic><topic>Cancer therapies</topic><topic>Colorectal cancer</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Fever</topic><topic>Heat</topic><topic>Hyperthermia</topic><topic>Infections</topic><topic>Ischemia</topic><topic>Original</topic><topic>Patients</topic><topic>Sepsis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Surgical site infections</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Attaallah, Wafi</creatorcontrib><creatorcontrib>Şen, Leyla Semiha</creatorcontrib><creatorcontrib>Aktan, Ahmet Özdemir</creatorcontrib><creatorcontrib>Ekşioğlu, Emel Demiralp</creatorcontrib><creatorcontrib>Eti, Zeynep</creatorcontrib><creatorcontrib>Güler, Sertaç Ata</creatorcontrib><creatorcontrib>Cingi, Asım</creatorcontrib><creatorcontrib>Department of Immunology, Marmara University School of Medicine, Istanbul, Turkey</creatorcontrib><creatorcontrib>Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey</creatorcontrib><creatorcontrib>Department of Anesthesia, Marmara University School of Medicine, Istanbul, Turkey</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Turkish journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Attaallah, Wafi</au><au>Şen, Leyla Semiha</au><au>Aktan, Ahmet Özdemir</au><au>Ekşioğlu, Emel Demiralp</au><au>Eti, Zeynep</au><au>Güler, Sertaç Ata</au><au>Cingi, Asım</au><aucorp>Department of Immunology, Marmara University School of Medicine, Istanbul, Turkey</aucorp><aucorp>Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey</aucorp><aucorp>Department of Anesthesia, Marmara University School of Medicine, Istanbul, Turkey</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does hyperthermic preconditioning affect the rate of surgical site infection rate and inflammatory reaction in colorectal cancer patients? A prospective randomized clinical trial</atitle><jtitle>Turkish journal of surgery</jtitle><addtitle>Turk J Surg</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>34</volume><issue>4</issue><spage>282</spage><epage>285</epage><pages>282-285</pages><issn>2564-6850</issn><eissn>2564-7032</eissn><abstract>Hyperthermic preconditioning has been shown to protect against different insults in experimental studies. However, clinical studies assessing its effects remain limited. The aim of this study was to investigate the effects of hyperthermic preconditioning on the rate of surgical site infection and inflammatory reaction in patients undergoing elective colorectal cancer surgery.
Patients with colorectal cancer, scheduled to undergo elective surgery were enrolled in this prospective randomized study. Patients were randomly assigned to either the hyperthermic preconditioning group or control group. Postoperative superficial and deep surgical site infection were recorded. Blood samples were collected from all the patients in the hyperthermic preconditioning group prior to the application of hyperthermia 12 h before surgery, immediately prior to surgery, and 4 h and 24 h postoperatively. For the control group, blood samples were obtained within the same periods without the application of hyperthermia. Levels of interleukin-1, IL-6, and tumor necrosis factor-α were measured from blood samples.
Twenty patients were randomized to the hyperthermic preconditioning group and 21 to the control group. No significant difference was found in deep or superficial surgical site infection between the groups. No significant difference in the tumor necrosis factor-α, interleukin-1, and IL-6 levels was found in serum samples collected before hyperthermia, during the operation, and postoperatively.
This study showed that hyperthermic preconditioning has no effect on the surgical site infection and cytokine response in patients undergoing elective surgical intervention for colorectal cancer.</abstract><cop>Turkey</cop><pub>Turkish Surgical Association</pub><pmid>30248285</pmid><doi>10.5152/turkjsurg.2018.3981</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Turkish journal of surgery, 2018-12, Vol.34 (4), p.282-285 |
| issn | 2564-6850 2564-7032 |
| language | eng |
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| source | PubMed Central |
| subjects | Blood transfusions Cancer therapies Colorectal cancer Cytokines Diabetes Fever Heat Hyperthermia Infections Ischemia Original Patients Sepsis Studies Surgery Surgical site infections Tumor necrosis factor-TNF |
| title | Does hyperthermic preconditioning affect the rate of surgical site infection rate and inflammatory reaction in colorectal cancer patients? A prospective randomized clinical trial |
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