Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren’s syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

A hallmark feature of pSS is B cell hyperactivity, including formation of autoantibodies, elevated serum IgG levels, increased numbers of B cells and IgG+/IgM+ plasma cells in salivary glands, and formation of germinal centre-like structures in the salivary glands associated with an increased risk o...

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Veröffentlicht in:	Rheumatic & musculoskeletal diseases open 2019-01, Vol.5 (1), p.e000701-e000701
Hauptverfasser:	Blokland, Sofie L M, Hillen, Maarten R, Wichers, Catharina G K, Zimmermann, Maili, Kruize, Aike A, Radstake, Timothy R D J, Broen, Jasper C A, van Roon, Joel A G
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomarkers Case-Control Studies Cell growth Cytokines - metabolism Disease Susceptibility Gene Expression Humans Immunophenotyping Insulin-like growth factors Kinases Lupus Lymphocyte Activation - immunology Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors Mechanistic Target of Rapamycin Complex 1 - metabolism Models, Biological Molecular Targeted Therapy Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Salivary Glands - immunology Salivary Glands - metabolism Salivary Glands - pathology Signal Transduction Sjogren's Syndrome - diagnosis Sjogren's Syndrome - drug therapy Sjogren's Syndrome - etiology Sjogren's Syndrome - metabolism Sjögren Syndrome T-Lymphocytes - immunology T-Lymphocytes - metabolism
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