Proximal human FOXP3 promoter transactivated by NF-κB and negatively controlled by feedback loop and SP3

Forkhead box protein 3 (Foxp3) is indispensable for the development of CD4 +CD25 + regulatory T cells (Tregs). Here we analyzed three prominent evolutionary conserved regions (ECRs) upstream of the transcription start site of the human FOXP3 gene. We show that ECR2 and ECR3 fragments derived from po...

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Veröffentlicht in:	Molecular immunology 2010-07, Vol.47 (11), p.2094-2102
Hauptverfasser:	Eckerstorfer, Paul, Novy, Michael, Burgstaller-Muehlbacher, Sebastian, Paster, Wolfgang, Schiller, Herbert B., Mayer, Herbert, Stockinger, Hannes
Format:	Artikel
Sprache:	eng
Schlagworte:	T cells Tolerance/suppression/anergy Transcription factors
Online-Zugang:	Volltext
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