Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC

As part of the continuing effort to develop an effective HIV vaccine, we generated a poxviral vaccine vector (previously described) designed to improve on the results of the RV144 phase III clinical trial. The construct, NYVAC-KC, is a replication-competent, attenuated recombinant of the vaccinia vi...

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Veröffentlicht in:	Journal of virology 2019-02, Vol.93 (3)
Hauptverfasser:	Kibler, Karen V, Asbach, Benedikt, Perdiguero, Beatriz, García-Arriaza, Juan, Yates, Nicole L, Parks, Robert, Stanfield-Oakley, Sherry, Ferrari, Guido, Montefiori, David C, Tomaras, Georgia D, Roederer, Mario, Foulds, Kathryn E, Forthal, Donald N, Seaman, Michael S, Self, Steve, Gottardo, Raphael, Phogat, Sanjay, Tartaglia, James, Barnett, Susan, Cristillo, Anthony D, Weiss, Deborah, Galmin, Lindsey, Ding, Song, Heeney, Jonathan L, Esteban, Mariano, Wagner, Ralf, Pantaleo, Giuseppe, Jacobs, Bertram L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - blood CD4-Positive T-Lymphocytes - immunology env Gene Products, Human Immunodeficiency Virus - immunology HIV Antibodies - blood HIV Antigens - immunology HIV Infections - immunology HIV Infections - prevention & control HIV Infections - virology HIV-1 - immunology Humans Macaca mulatta Male Vaccination Vaccines and Antiviral Agents Vaccinia virus - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus Replication
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