MicroRNA and Human Bone Health
The small non-coding microRNAs (miRNAs) are post-transcription regulators that modulate diverse cellular process in bone cells. Because optimal miRNA targeting is essential for their function, single-nucleotide polymorphisms (SNPs) within or proximal to the loci of miRNA (miR-SNPs) or mRNA (PolymiRT...
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| description | The small non-coding microRNAs (miRNAs) are post-transcription regulators that modulate diverse cellular process in bone cells. Because optimal miRNA targeting is essential for their function, single-nucleotide polymorphisms (SNPs) within or proximal to the loci of miRNA (miR-SNPs) or mRNA (PolymiRTS) could potentially disrupt the miRNA-mRNA interaction, leading to changes in bone metabolism and osteoporosis. Recent human studies of skeletal traits using miRNA profiling, genomewide association studies, and functional studies started to decipher the complex miRNA regulatory network. These studies have indicated that miRNAs may be a promising bone marker. This review focuses on human miRNA studies on bone traits and discusses how genetic variants affect bone metabolic pathways. Major ex vivo investigations using human samples supported with animal and in vitro models have shed light on the mechanistic role of miRNAs. Furthermore, studying the miRNAs' signatures in secondary osteoporosis and osteoporotic medications such as teriparatide (TPTD) and denosumab (DMab) have provided valuable insight into clinical management of the disease. © 2018 The Authors.
Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research. |
| doi_str_mv | 10.1002/jbm4.10115 |
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Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.</description><identifier>ISSN: 2473-4039</identifier><identifier>EISSN: 2473-4039</identifier><identifier>DOI: 10.1002/jbm4.10115</identifier><identifier>PMID: 30680358</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animal models ; Biomarkers ; Biosynthesis ; Bone turnover ; Fractures ; Genes ; Genetic diversity ; Medical research ; Metabolic pathways ; Metabolism ; MicroRNAs ; miRNA ; Monoclonal antibodies ; Mutation ; Osteoporosis ; Parathyroid hormone ; Review ; Risk assessment ; Single-nucleotide polymorphism ; Transcription ; Womens health</subject><ispartof>JBMR plus, 2019-01, Vol.3 (1), p.2-13</ispartof><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 The Authors. Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-18258fc132c9bb0fee9a83cb6526025f4b723ebaab142ab2243b24ec130ca4283</citedby><cites>FETCH-LOGICAL-c406t-18258fc132c9bb0fee9a83cb6526025f4b723ebaab142ab2243b24ec130ca4283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339549/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339549/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30680358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Vincent Ka-Fai</creatorcontrib><creatorcontrib>Au, Philip Chun-Ming</creatorcontrib><creatorcontrib>Tan, Kathryn Cb</creatorcontrib><creatorcontrib>Cheung, Ching-Lung</creatorcontrib><title>MicroRNA and Human Bone Health</title><title>JBMR plus</title><addtitle>JBMR Plus</addtitle><description>The small non-coding microRNAs (miRNAs) are post-transcription regulators that modulate diverse cellular process in bone cells. Because optimal miRNA targeting is essential for their function, single-nucleotide polymorphisms (SNPs) within or proximal to the loci of miRNA (miR-SNPs) or mRNA (PolymiRTS) could potentially disrupt the miRNA-mRNA interaction, leading to changes in bone metabolism and osteoporosis. Recent human studies of skeletal traits using miRNA profiling, genomewide association studies, and functional studies started to decipher the complex miRNA regulatory network. These studies have indicated that miRNAs may be a promising bone marker. This review focuses on human miRNA studies on bone traits and discusses how genetic variants affect bone metabolic pathways. Major ex vivo investigations using human samples supported with animal and in vitro models have shed light on the mechanistic role of miRNAs. Furthermore, studying the miRNAs' signatures in secondary osteoporosis and osteoporotic medications such as teriparatide (TPTD) and denosumab (DMab) have provided valuable insight into clinical management of the disease. © 2018 The Authors.
Published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.</description><subject>Animal models</subject><subject>Biomarkers</subject><subject>Biosynthesis</subject><subject>Bone turnover</subject><subject>Fractures</subject><subject>Genes</subject><subject>Genetic diversity</subject><subject>Medical research</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Monoclonal antibodies</subject><subject>Mutation</subject><subject>Osteoporosis</subject><subject>Parathyroid hormone</subject><subject>Review</subject><subject>Risk assessment</subject><subject>Single-nucleotide polymorphism</subject><subject>Transcription</subject><subject>Womens health</subject><issn>2473-4039</issn><issn>2473-4039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkNFKwzAUhoMobszd-ACj4I0I1eQkTdMbYQ51wlQQvQ5JlrqOtplNK_j2Zm6O6VV-yHd-zvkQOiX4kmAMV0tdsZAISQ5QH1hKY4ZpdriXe2jo_RJjTFJBE8GPUY9iLnDIfTR6LEzjXp7Gkarn0bSrVB3duNpGU6vKdnGCjnJVejvcvgP0dnf7OpnGs-f7h8l4FhuGeRsTAYnIDaFgMq1xbm2mBDWaJ8AxJDnTKVCrldKEgdIAjGpgNgxgoxgIOkDXm95Vpys7N7ZuG1XKVVNUqvmSThXy709dLOS7-5Sc0ixhWSg43xY07qOzvpVV4Y0tS1Vb13kJJM0Y4SzjAT37hy5d19ThPAkgBCcsnBOoiw0V9Hjf2Hy3DMFybV6uzcsf8wEe7a-_Q389028e23ub</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Cheng, Vincent Ka-Fai</creator><creator>Au, Philip Chun-Ming</creator><creator>Tan, Kathryn Cb</creator><creator>Cheung, Ching-Lung</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>MicroRNA and Human Bone Health</title><author>Cheng, Vincent Ka-Fai ; Au, Philip Chun-Ming ; Tan, Kathryn Cb ; Cheung, Ching-Lung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-18258fc132c9bb0fee9a83cb6526025f4b723ebaab142ab2243b24ec130ca4283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>Biomarkers</topic><topic>Biosynthesis</topic><topic>Bone turnover</topic><topic>Fractures</topic><topic>Genes</topic><topic>Genetic diversity</topic><topic>Medical research</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Monoclonal antibodies</topic><topic>Mutation</topic><topic>Osteoporosis</topic><topic>Parathyroid hormone</topic><topic>Review</topic><topic>Risk assessment</topic><topic>Single-nucleotide polymorphism</topic><topic>Transcription</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Vincent Ka-Fai</creatorcontrib><creatorcontrib>Au, Philip Chun-Ming</creatorcontrib><creatorcontrib>Tan, Kathryn Cb</creatorcontrib><creatorcontrib>Cheung, Ching-Lung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JBMR plus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Vincent Ka-Fai</au><au>Au, Philip Chun-Ming</au><au>Tan, Kathryn Cb</au><au>Cheung, Ching-Lung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA and Human Bone Health</atitle><jtitle>JBMR plus</jtitle><addtitle>JBMR Plus</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>3</volume><issue>1</issue><spage>2</spage><epage>13</epage><pages>2-13</pages><issn>2473-4039</issn><eissn>2473-4039</eissn><abstract>The small non-coding microRNAs (miRNAs) are post-transcription regulators that modulate diverse cellular process in bone cells. Because optimal miRNA targeting is essential for their function, single-nucleotide polymorphisms (SNPs) within or proximal to the loci of miRNA (miR-SNPs) or mRNA (PolymiRTS) could potentially disrupt the miRNA-mRNA interaction, leading to changes in bone metabolism and osteoporosis. Recent human studies of skeletal traits using miRNA profiling, genomewide association studies, and functional studies started to decipher the complex miRNA regulatory network. These studies have indicated that miRNAs may be a promising bone marker. This review focuses on human miRNA studies on bone traits and discusses how genetic variants affect bone metabolic pathways. Major ex vivo investigations using human samples supported with animal and in vitro models have shed light on the mechanistic role of miRNAs. Furthermore, studying the miRNAs' signatures in secondary osteoporosis and osteoporotic medications such as teriparatide (TPTD) and denosumab (DMab) have provided valuable insight into clinical management of the disease. © 2018 The Authors.
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| subjects | Animal models Biomarkers Biosynthesis Bone turnover Fractures Genes Genetic diversity Medical research Metabolic pathways Metabolism MicroRNAs miRNA Monoclonal antibodies Mutation Osteoporosis Parathyroid hormone Review Risk assessment Single-nucleotide polymorphism Transcription Womens health |
| title | MicroRNA and Human Bone Health |
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