Cold Atmospheric Pressure Plasma Comb-A Physical Approach for Pediculosis Treatment
Pediculosis, that is the infestation of humans with (head lice), poses a worldwide problem that is as old as mankind itself. Over the centuries, man has developed a variety of remedies, all of which have ultimately culminated in the use of chemical agents. Some of these remedies are known to produce...
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| Veröffentlicht in: | International journal of environmental research and public health 2018-12, Vol.16 (1), p.19 |
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| creator | Ten Bosch, Lars Habedank, Birgit Siebert, Dominik Mrotzek, Julia Viöl, Wolfgang |
| description | Pediculosis, that is the infestation of humans with
(head lice), poses a worldwide problem that is as old as mankind itself. Over the centuries, man has developed a variety of remedies, all of which have ultimately culminated in the use of chemical agents. Some of these remedies are known to produce successful results. A large portion of the effective remedies used to kill lice and their eggs contain insecticides, but there is an increasing number of reports of head lice populations revealing an increased resistance. This study presents an alternative treatment approach, the efficacy of which is based on physical effects. Cold atmospheric pressure plasmas have successfully shown their formidably wide application range within the field of plasma medicine. This study presents a plasma device in its current stage of development that is engineered as a consumer product to enable an alternative physical and insecticide-free option for the treatment of pediculosis. An efficacy study concerning different developmental stages of
is presented.
was chosen as a substitute test organism for
due to possible laboratory rearing and high anatomic similarity. The study shows how a single stroke of the plasma device over a hair strand (approximately 22 cm in length with a weight of 1.5 g) led to mortality rates of 68.3% (50.0; 79.7) (95% CI) in the juvenile test group, a mortality rate of approx. 67.7% (54.9; 78.8) (95% CI) in the female test group, and approx. 46.7% (28.3; 65.7) (95% CI) in the male test group. When single eggs were introduced directly into the plasma for approx. 1 s, younger eggs (0⁻2 d) showed a higher mortality of 66.7% (42.7; 82.7) than the older (4⁻6 d) eggs, with 16.7% (5.6; 34.7) (CI). Furthermore, the results of a risk assessment of the device are described. The article concludes with necessary handling instructions as well as further developmental steps, derived from the results of the efficacy and the risk assessment study. |
| doi_str_mv | 10.3390/ijerph16010019 |
| format | Article |
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(head lice), poses a worldwide problem that is as old as mankind itself. Over the centuries, man has developed a variety of remedies, all of which have ultimately culminated in the use of chemical agents. Some of these remedies are known to produce successful results. A large portion of the effective remedies used to kill lice and their eggs contain insecticides, but there is an increasing number of reports of head lice populations revealing an increased resistance. This study presents an alternative treatment approach, the efficacy of which is based on physical effects. Cold atmospheric pressure plasmas have successfully shown their formidably wide application range within the field of plasma medicine. This study presents a plasma device in its current stage of development that is engineered as a consumer product to enable an alternative physical and insecticide-free option for the treatment of pediculosis. An efficacy study concerning different developmental stages of
is presented.
was chosen as a substitute test organism for
due to possible laboratory rearing and high anatomic similarity. The study shows how a single stroke of the plasma device over a hair strand (approximately 22 cm in length with a weight of 1.5 g) led to mortality rates of 68.3% (50.0; 79.7) (95% CI) in the juvenile test group, a mortality rate of approx. 67.7% (54.9; 78.8) (95% CI) in the female test group, and approx. 46.7% (28.3; 65.7) (95% CI) in the male test group. When single eggs were introduced directly into the plasma for approx. 1 s, younger eggs (0⁻2 d) showed a higher mortality of 66.7% (42.7; 82.7) than the older (4⁻6 d) eggs, with 16.7% (5.6; 34.7) (CI). Furthermore, the results of a risk assessment of the device are described. The article concludes with necessary handling instructions as well as further developmental steps, derived from the results of the efficacy and the risk assessment study.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph16010019</identifier><identifier>PMID: 30577656</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Binding sites ; Dermatology - instrumentation ; Eggs ; Electrodes ; Electron energy ; Emission spectroscopy ; Experiments ; Female ; Field strength ; Hair ; Humans ; Humidity ; Insecticides ; Laboratories ; Lice ; Lice Infestations - therapy ; Male ; Medical equipment ; Mortality ; Optical emission spectroscopy ; Pediculus - physiology ; Pesticides ; Plasma ; Plasma Gases - standards ; Plasma Gases - therapeutic use ; Plasma jets ; Rabbits ; Relative humidity ; Rotational spectra ; Spectroscopy ; Spectrum analysis ; Survival Analysis ; Test organisms ; Toxicity</subject><ispartof>International journal of environmental research and public health, 2018-12, Vol.16 (1), p.19</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3339-5a93c52f9f9d9f607e1b2be071a769182fa82fd142c9610105126822fab5356d3</citedby><cites>FETCH-LOGICAL-c3339-5a93c52f9f9d9f607e1b2be071a769182fa82fd142c9610105126822fab5356d3</cites><orcidid>0000-0003-3425-9937 ; 0000-0002-5385-7492 ; 0000-0002-2848-3476 ; 0000-0002-7711-3893 ; 0000-0002-4322-5985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338894/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338894/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30577656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ten Bosch, Lars</creatorcontrib><creatorcontrib>Habedank, Birgit</creatorcontrib><creatorcontrib>Siebert, Dominik</creatorcontrib><creatorcontrib>Mrotzek, Julia</creatorcontrib><creatorcontrib>Viöl, Wolfgang</creatorcontrib><title>Cold Atmospheric Pressure Plasma Comb-A Physical Approach for Pediculosis Treatment</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Pediculosis, that is the infestation of humans with
(head lice), poses a worldwide problem that is as old as mankind itself. Over the centuries, man has developed a variety of remedies, all of which have ultimately culminated in the use of chemical agents. Some of these remedies are known to produce successful results. A large portion of the effective remedies used to kill lice and their eggs contain insecticides, but there is an increasing number of reports of head lice populations revealing an increased resistance. This study presents an alternative treatment approach, the efficacy of which is based on physical effects. Cold atmospheric pressure plasmas have successfully shown their formidably wide application range within the field of plasma medicine. This study presents a plasma device in its current stage of development that is engineered as a consumer product to enable an alternative physical and insecticide-free option for the treatment of pediculosis. An efficacy study concerning different developmental stages of
is presented.
was chosen as a substitute test organism for
due to possible laboratory rearing and high anatomic similarity. The study shows how a single stroke of the plasma device over a hair strand (approximately 22 cm in length with a weight of 1.5 g) led to mortality rates of 68.3% (50.0; 79.7) (95% CI) in the juvenile test group, a mortality rate of approx. 67.7% (54.9; 78.8) (95% CI) in the female test group, and approx. 46.7% (28.3; 65.7) (95% CI) in the male test group. When single eggs were introduced directly into the plasma for approx. 1 s, younger eggs (0⁻2 d) showed a higher mortality of 66.7% (42.7; 82.7) than the older (4⁻6 d) eggs, with 16.7% (5.6; 34.7) (CI). Furthermore, the results of a risk assessment of the device are described. The article concludes with necessary handling instructions as well as further developmental steps, derived from the results of the efficacy and the risk assessment study.</description><subject>Animals</subject><subject>Binding sites</subject><subject>Dermatology - instrumentation</subject><subject>Eggs</subject><subject>Electrodes</subject><subject>Electron energy</subject><subject>Emission spectroscopy</subject><subject>Experiments</subject><subject>Female</subject><subject>Field strength</subject><subject>Hair</subject><subject>Humans</subject><subject>Humidity</subject><subject>Insecticides</subject><subject>Laboratories</subject><subject>Lice</subject><subject>Lice Infestations - therapy</subject><subject>Male</subject><subject>Medical equipment</subject><subject>Mortality</subject><subject>Optical emission spectroscopy</subject><subject>Pediculus - physiology</subject><subject>Pesticides</subject><subject>Plasma</subject><subject>Plasma Gases - standards</subject><subject>Plasma Gases - therapeutic use</subject><subject>Plasma jets</subject><subject>Rabbits</subject><subject>Relative humidity</subject><subject>Rotational spectra</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Survival Analysis</subject><subject>Test organisms</subject><subject>Toxicity</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LwzAYxoMobk6vHiXgxUtnPpq0uQhj-AUDB85zSNPUZrRLTVZh_72RzbF5CG-S95cn78MDwDVGY0oFurdL47sac4QRwuIEDDHnKEnj-fRgPwAXISwRonnKxTkYUMSyjDM-BO9T15Rwsm5d6GrjrYZzb0LovYHzRoVWwalri2QC5_UmWK0aOOk675SuYeU8nJvS6r5xwQa48EatW7NaX4KzSjXBXO3qCHw8PS6mL8ns7fl1OpklmsbZE6YE1YxUohKlqDjKDC5IYVCGVcYFzkml4ipxSrTgOBpkmPCcxOuCUcZLOgIPW92uL1pT6vi1V43svG2V30inrDzurGwtP9235JTmuUijwN1OwLuv3oS1bG3QpmnUyrg-SIKZEHlGchHR23_o0vV-Fe1JQiOQCsRZpMZbSnsXgjfVfhiM5G9e8jiv-ODm0MIe_wuI_gCijpGF</recordid><startdate>20181221</startdate><enddate>20181221</enddate><creator>Ten Bosch, Lars</creator><creator>Habedank, Birgit</creator><creator>Siebert, Dominik</creator><creator>Mrotzek, Julia</creator><creator>Viöl, Wolfgang</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3425-9937</orcidid><orcidid>https://orcid.org/0000-0002-5385-7492</orcidid><orcidid>https://orcid.org/0000-0002-2848-3476</orcidid><orcidid>https://orcid.org/0000-0002-7711-3893</orcidid><orcidid>https://orcid.org/0000-0002-4322-5985</orcidid></search><sort><creationdate>20181221</creationdate><title>Cold Atmospheric Pressure Plasma Comb-A Physical Approach for Pediculosis Treatment</title><author>Ten Bosch, Lars ; 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(head lice), poses a worldwide problem that is as old as mankind itself. Over the centuries, man has developed a variety of remedies, all of which have ultimately culminated in the use of chemical agents. Some of these remedies are known to produce successful results. A large portion of the effective remedies used to kill lice and their eggs contain insecticides, but there is an increasing number of reports of head lice populations revealing an increased resistance. This study presents an alternative treatment approach, the efficacy of which is based on physical effects. Cold atmospheric pressure plasmas have successfully shown their formidably wide application range within the field of plasma medicine. This study presents a plasma device in its current stage of development that is engineered as a consumer product to enable an alternative physical and insecticide-free option for the treatment of pediculosis. An efficacy study concerning different developmental stages of
is presented.
was chosen as a substitute test organism for
due to possible laboratory rearing and high anatomic similarity. The study shows how a single stroke of the plasma device over a hair strand (approximately 22 cm in length with a weight of 1.5 g) led to mortality rates of 68.3% (50.0; 79.7) (95% CI) in the juvenile test group, a mortality rate of approx. 67.7% (54.9; 78.8) (95% CI) in the female test group, and approx. 46.7% (28.3; 65.7) (95% CI) in the male test group. When single eggs were introduced directly into the plasma for approx. 1 s, younger eggs (0⁻2 d) showed a higher mortality of 66.7% (42.7; 82.7) than the older (4⁻6 d) eggs, with 16.7% (5.6; 34.7) (CI). Furthermore, the results of a risk assessment of the device are described. The article concludes with necessary handling instructions as well as further developmental steps, derived from the results of the efficacy and the risk assessment study.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30577656</pmid><doi>10.3390/ijerph16010019</doi><orcidid>https://orcid.org/0000-0003-3425-9937</orcidid><orcidid>https://orcid.org/0000-0002-5385-7492</orcidid><orcidid>https://orcid.org/0000-0002-2848-3476</orcidid><orcidid>https://orcid.org/0000-0002-7711-3893</orcidid><orcidid>https://orcid.org/0000-0002-4322-5985</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Binding sites Dermatology - instrumentation Eggs Electrodes Electron energy Emission spectroscopy Experiments Female Field strength Hair Humans Humidity Insecticides Laboratories Lice Lice Infestations - therapy Male Medical equipment Mortality Optical emission spectroscopy Pediculus - physiology Pesticides Plasma Plasma Gases - standards Plasma Gases - therapeutic use Plasma jets Rabbits Relative humidity Rotational spectra Spectroscopy Spectrum analysis Survival Analysis Test organisms Toxicity |
| title | Cold Atmospheric Pressure Plasma Comb-A Physical Approach for Pediculosis Treatment |
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