Smooth muscle brain‐derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma

ABSTRACT Recent studies have demonstrated an effect of neurotrophins, particularly brain‐derived neurotrophic factor (BDNF), on airway contractility [via increased airway smooth muscle (ASM) intracellular calcium [Ca2+]i] and remodeling (ASM proliferation and extracellular matrix formation) in the c...

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Veröffentlicht in:	The FASEB journal 2019-02, Vol.33 (2), p.3024-3034
Hauptverfasser:	Britt, Rodney D., Thompson, Michael A., Wicher, Sarah A., Manlove, Logan J., Roesler, Anne, Fang, Yun-Hua, Roos, Carolyn, Smith, Leslie, Miller, Jordan D., Pabelick, Christina M., Prakash, Y. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Remodeling - drug effects Allergens - adverse effects Animals Asthma - chemically induced Asthma - physiopathology Brain-Derived Neurotrophic Factor - physiology Bronchial Hyperreactivity - etiology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - pathology Disease Models, Animal extracellular matrix Female fibrosis Inflammation - etiology Inflammation - metabolism Inflammation - pathology Male Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - physiology Mice Mice, Knockout Mice, Transgenic Muscle Contraction Muscle, Smooth - cytology Muscle, Smooth - metabolism neurotrophin Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - physiology Pyrazoles - pharmacology Pyrimidines - pharmacology Respiratory System - physiopathology TrkB
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