The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity

White adipose tissue (WAT) can dynamically expand and remodel through adipocyte hypertrophy and hyperplasia. The relative contribution of these 2 mechanisms to WAT expansion is a critical determinant of WAT function and dysfunction in obesity. However, little is known about the signaling systems tha...

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Veröffentlicht in:	JCI insight 2018-12, Vol.3 (24)
Hauptverfasser:	Yanagida, Keisuke, Igarashi, Hidemitsu, Yasuda, Daisuke, Kobayashi, Daiki, Ohto-Nakanishi, Takayo, Akahoshi, Noriyuki, Sekiba, Atsushi, Toyoda, Tsudoi, Ishijima, Tomoko, Nakai, Yuji, Shojima, Nobuhiro, Kubota, Naoto, Abe, Keiko, Kadowaki, Takashi, Ishii, Satoshi, Shimizu, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipogenesis - genetics Adiponectin - metabolism Adipose Tissue - metabolism Adipose Tissue - pathology Adipose Tissue, White - metabolism Animals Diet, High-Fat Disease Models, Animal Fibroblasts Gene Expression Regulation Glucose Tolerance Test GTP-Binding Protein alpha Subunits, G12-G13 - metabolism Insulin - metabolism Insulin Resistance Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Obesity - genetics Obesity - metabolism Obesity - pathology Phosphorylation PPAR gamma - metabolism Receptors, Purinergic - genetics Receptors, Purinergic - metabolism Signal Transduction Tissue Expansion - methods
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