Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents
Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhe...
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| Veröffentlicht in: | Bioengineering & translational medicine 2019-01, Vol.4 (1), p.129-140 |
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| creator | Suh, Hee‐Won Lewis, Julia Fong, Linda Ramseier, Julie Ying Carlson, Kacie Peng, Zheng‐Hong Yin, Emily Sara Saltzman, W. Mark Girardi, Michael |
| description | Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhesive biodegradable nanoparticles (BNPs) composed of poly(d,l‐lactic acid)‐hyperbranched polyglycerol was previously shown to enhance UVR protection while preventing skin absorption. Herein, we assess the capacity of BNP co‐incorporation of avobenzone and octocrylene to provide broad‐spectrum UVR protection. The ratio of UV filters within nanoparticles (NPs) was optimized for filter–filter stabilization upon UV irradiation and maximum drug loading. In vitro water‐resistance test showed significant particle retention at 85% over 3 hr. In a pilot clinical study, protection against UVR‐induced erythema of BNPs was found to be comparable to the FDA standard P2. Thus, sunscreen formulations utilizing BNP incorporation of a combination of organic filters may offer key safety and performance advantages. |
| doi_str_mv | 10.1002/btm2.10092 |
| format | Article |
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Mark ; Girardi, Michael</creator><creatorcontrib>Suh, Hee‐Won ; Lewis, Julia ; Fong, Linda ; Ramseier, Julie Ying ; Carlson, Kacie ; Peng, Zheng‐Hong ; Yin, Emily Sara ; Saltzman, W. Mark ; Girardi, Michael</creatorcontrib><description>Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhesive biodegradable nanoparticles (BNPs) composed of poly(d,l‐lactic acid)‐hyperbranched polyglycerol was previously shown to enhance UVR protection while preventing skin absorption. Herein, we assess the capacity of BNP co‐incorporation of avobenzone and octocrylene to provide broad‐spectrum UVR protection. The ratio of UV filters within nanoparticles (NPs) was optimized for filter–filter stabilization upon UV irradiation and maximum drug loading. In vitro water‐resistance test showed significant particle retention at 85% over 3 hr. In a pilot clinical study, protection against UVR‐induced erythema of BNPs was found to be comparable to the FDA standard P2. Thus, sunscreen formulations utilizing BNP incorporation of a combination of organic filters may offer key safety and performance advantages.</description><identifier>ISSN: 2380-6761</identifier><identifier>EISSN: 2380-6761</identifier><identifier>DOI: 10.1002/btm2.10092</identifier><identifier>PMID: 30680324</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Biodegradability ; Chromatography ; clinical study ; Dermatitis ; drug delivery ; FDA approval ; Formulations ; In vitro methods and tests ; Lactic acid ; nanoparticle ; Nanoparticles ; Octocrylene ; Photodegradation ; Polyglycerols ; Polymers ; Radiation damage ; reactive oxygen species ; Research Report ; Research Reports ; Retention ; Skin cancer ; Studies ; Sun screens ; Sunburn & sun tanning ; Sunscreen ; Ultraviolet filters ; Ultraviolet radiation ; UV stabilizers ; Water purification</subject><ispartof>Bioengineering & translational medicine, 2019-01, Vol.4 (1), p.129-140</ispartof><rights>2018 The Authors. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3782-9a37ab3ae4b7dfddb53fa07e79aa2d902c360e3fc07a78f87476e384bc9a54ab3</citedby><cites>FETCH-LOGICAL-c3782-9a37ab3ae4b7dfddb53fa07e79aa2d902c360e3fc07a78f87476e384bc9a54ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336670/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336670/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30680324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suh, Hee‐Won</creatorcontrib><creatorcontrib>Lewis, Julia</creatorcontrib><creatorcontrib>Fong, Linda</creatorcontrib><creatorcontrib>Ramseier, Julie Ying</creatorcontrib><creatorcontrib>Carlson, Kacie</creatorcontrib><creatorcontrib>Peng, Zheng‐Hong</creatorcontrib><creatorcontrib>Yin, Emily Sara</creatorcontrib><creatorcontrib>Saltzman, W. Mark</creatorcontrib><creatorcontrib>Girardi, Michael</creatorcontrib><title>Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents</title><title>Bioengineering & translational medicine</title><addtitle>Bioeng Transl Med</addtitle><description>Conventional emulsion‐based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposure. Encapsulation of the UVB filter padimate O within bioadhesive biodegradable nanoparticles (BNPs) composed of poly(d,l‐lactic acid)‐hyperbranched polyglycerol was previously shown to enhance UVR protection while preventing skin absorption. Herein, we assess the capacity of BNP co‐incorporation of avobenzone and octocrylene to provide broad‐spectrum UVR protection. The ratio of UV filters within nanoparticles (NPs) was optimized for filter–filter stabilization upon UV irradiation and maximum drug loading. In vitro water‐resistance test showed significant particle retention at 85% over 3 hr. In a pilot clinical study, protection against UVR‐induced erythema of BNPs was found to be comparable to the FDA standard P2. Thus, sunscreen formulations utilizing BNP incorporation of a combination of organic filters may offer key safety and performance advantages.</description><subject>Biodegradability</subject><subject>Chromatography</subject><subject>clinical study</subject><subject>Dermatitis</subject><subject>drug delivery</subject><subject>FDA approval</subject><subject>Formulations</subject><subject>In vitro methods and tests</subject><subject>Lactic acid</subject><subject>nanoparticle</subject><subject>Nanoparticles</subject><subject>Octocrylene</subject><subject>Photodegradation</subject><subject>Polyglycerols</subject><subject>Polymers</subject><subject>Radiation damage</subject><subject>reactive oxygen species</subject><subject>Research Report</subject><subject>Research Reports</subject><subject>Retention</subject><subject>Skin cancer</subject><subject>Studies</subject><subject>Sun screens</subject><subject>Sunburn & sun tanning</subject><subject>Sunscreen</subject><subject>Ultraviolet filters</subject><subject>Ultraviolet radiation</subject><subject>UV stabilizers</subject><subject>Water purification</subject><issn>2380-6761</issn><issn>2380-6761</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc9O3DAQhy3UChDdSx8AReJSVdri2Fk7viAV1D9IIC7bszV2JotRYgc7AXHrI_QZeRK8LCDoAfngkebz5xn9CPlc0m8lpezQjD1bV4ptkV3GazoXUpQfXtU7ZJbSFaW0FCXndbVNdjgVNeWs2iVw7EKDqwgNmA4L4wI0l5jcDRYefBggjs7mhvM2xCFEGF3wRWgLEzN5__dfGtCOceqLEFfgnS3S5JONiL6AFfoxfSIfW-gSzp7uPfLn54_lye_52cWv05PvZ3PLZc3mCrgEwwErI5u2acyCt0AlSgXAGkWZ5YIiby2VIOu2lpUUmLcxVsGiyi_3yNHGO0ymx8bmvyN0eoiuh3inAzj9tuPdpV6FGy04F0LSLPjyJIjhesI06t4li10HHsOUNCulqjjNJ6MH_6FXYYo-r6cZq1UtFkKpTH3dUDaGlCK2L8OUVK_D0-vw9GN4Gd5_Pf4L-hxVBsoNcOs6vHtHpY-X52wjfQA4Aaff</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Suh, Hee‐Won</creator><creator>Lewis, Julia</creator><creator>Fong, Linda</creator><creator>Ramseier, Julie Ying</creator><creator>Carlson, Kacie</creator><creator>Peng, Zheng‐Hong</creator><creator>Yin, Emily Sara</creator><creator>Saltzman, W. Mark</creator><creator>Girardi, Michael</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201901</creationdate><title>Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents</title><author>Suh, Hee‐Won ; Lewis, Julia ; Fong, Linda ; Ramseier, Julie Ying ; Carlson, Kacie ; Peng, Zheng‐Hong ; Yin, Emily Sara ; Saltzman, W. 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| subjects | Biodegradability Chromatography clinical study Dermatitis drug delivery FDA approval Formulations In vitro methods and tests Lactic acid nanoparticle Nanoparticles Octocrylene Photodegradation Polyglycerols Polymers Radiation damage reactive oxygen species Research Report Research Reports Retention Skin cancer Studies Sun screens Sunburn & sun tanning Sunscreen Ultraviolet filters Ultraviolet radiation UV stabilizers Water purification |
| title | Biodegradable bioadhesive nanoparticle incorporation of broad‐spectrum organic sunscreen agents |
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