Pharmacogenetic association between NAT2 gene polymorphisms and isoniazid induced hepatotoxicity: trial sequence meta-analysis as evidence

Hepatotoxicity is a severe problem generally faced by tuberculosis (TB) patients. It is a well-known adverse reaction due to anti-TB drugs in TB patients undergoing long-term treatment. The studies published previously have explored the connection of N-acetyltransferase 2 ( ) gene polymorphisms with...

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Veröffentlicht in:	Bioscience reports 2019-01, Vol.39 (1)
Hauptverfasser:	Khan, Saif, Mandal, Raju K, Elasbali, Abdulbaset Mohamed, Dar, Sajad A, Jawed, Arshad, Wahid, Mohd, Mahto, Harishankar, Lohani, Mohtashim, Mishra, Bhartendu Nath, Akhter, Naseem, Rabaan, Ali A, Haque, Shafiul
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antitubercular Agents - administration & dosage Antitubercular Agents - adverse effects Arylamine N-Acetyltransferase - genetics Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - pathology Clinical Trials as Topic Gene Expression Gene Frequency Genetic Predisposition to Disease Humans Isoniazid - administration & dosage Isoniazid - adverse effects Liver - drug effects Liver - enzymology Liver - pathology Mycobacterium tuberculosis - drug effects Polymorphism, Single Nucleotide Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology
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