Preparation of stable tau oligomers for cellular and biochemical studies

Increasing evidence suggests that small oligomers are the principal neurotoxic species of tau in Alzheimer's disease and other tauopathies. However, mechanisms of tau oligomer-mediated neurodegeneration are poorly understood. The transience of oligomers due to aggregation can compromise the sta...

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Veröffentlicht in:	Analytical biochemistry 2019-02, Vol.566, p.67-74
Hauptverfasser:	Karikari, Thomas K., Nagel, David A., Grainger, Alastair, Clarke-Bland, Charlotte, Hill, Eric J., Moffat, Kevin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Biomarkers - chemistry Cells, Cultured Humans iPSC-derived neurons Maleimide Neurons - metabolism Oligomer Protein Conformation Tau tau Proteins - chemistry Tauopathies
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