PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation

Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage cancers, often show signs of a telomere crisi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncotarget 2018-12, Vol.9 (101), p.37549-37563
Hauptverfasser:	Ngo, Greg, Hyatt, Sam, Grimstead, Julia, Jones, Rhiannon, Hendrickson, Eric, Pepper, Chris, Baird, Duncan
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!