White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease
OBJECTIVETo evaluate microstructural characteristics of the corpus callosum using diffusion tensor imaging (DTI) and their relationships to cognitive impairment in Parkinson disease (PD). METHODSSeventy-five participants with PD and 24 healthy control (HC) participants underwent structural MRI brain...
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| Veröffentlicht in: | Neurology 2018-12, Vol.91 (24), p.e2244-e2255 |
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| creator | Bledsoe, Ian O Stebbins, Glenn T Merkitch, Doug Goldman, Jennifer G |
| description | OBJECTIVETo evaluate microstructural characteristics of the corpus callosum using diffusion tensor imaging (DTI) and their relationships to cognitive impairment in Parkinson disease (PD).
METHODSSeventy-five participants with PD and 24 healthy control (HC) participants underwent structural MRI brain scans including DTI sequences and clinical and neuropsychological evaluations. Using Movement Disorder Society criteria, PD participants were classified as having normal cognition (PD-NC, n = 23), mild cognitive impairment (PD-MCI, n = 35), or dementia (PDD, n = 17). Cognitive domain (attention/working memory, executive function, language, memory, visuospatial function) z scores were calculated. DTI scalar values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were established for 5 callosal segments on a midsagittal plane, single slice using a topographically derived parcellation method. Scalar values were compared among participant groups. Regression analyses were performed on cognitive domain z scores and DTI metrics.
RESULTSParticipants with PD showed increased AD values in the anterior 3 callosal segments compared to healthy controls. Participants with PDD had significantly increased AD, MD, and RD in the anterior 2 segments compared to participants with PD-NC and most anterior segment compared to participants with PD-MCI. FA values did not differ significantly between participants with PD and participants with HC or among PD cognitive groups. The strongest associations for the DTI metrics and cognitive performance occurred in the most anterior and most posterior callosal segments, and also reflected fronto-striatal and posterior cortical type cognitive deficits, respectively.
CONCLUSIONSMicrostructural white matter abnormalities of the corpus callosum, as measured by DTI, may contribute to PD cognitive impairment by disrupting information transfer across interhemispheric and callosal–cortical projections. |
| doi_str_mv | 10.1212/WNL.0000000000006646 |
| format | Article |
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METHODSSeventy-five participants with PD and 24 healthy control (HC) participants underwent structural MRI brain scans including DTI sequences and clinical and neuropsychological evaluations. Using Movement Disorder Society criteria, PD participants were classified as having normal cognition (PD-NC, n = 23), mild cognitive impairment (PD-MCI, n = 35), or dementia (PDD, n = 17). Cognitive domain (attention/working memory, executive function, language, memory, visuospatial function) z scores were calculated. DTI scalar values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were established for 5 callosal segments on a midsagittal plane, single slice using a topographically derived parcellation method. Scalar values were compared among participant groups. Regression analyses were performed on cognitive domain z scores and DTI metrics.
RESULTSParticipants with PD showed increased AD values in the anterior 3 callosal segments compared to healthy controls. Participants with PDD had significantly increased AD, MD, and RD in the anterior 2 segments compared to participants with PD-NC and most anterior segment compared to participants with PD-MCI. FA values did not differ significantly between participants with PD and participants with HC or among PD cognitive groups. The strongest associations for the DTI metrics and cognitive performance occurred in the most anterior and most posterior callosal segments, and also reflected fronto-striatal and posterior cortical type cognitive deficits, respectively.
CONCLUSIONSMicrostructural white matter abnormalities of the corpus callosum, as measured by DTI, may contribute to PD cognitive impairment by disrupting information transfer across interhemispheric and callosal–cortical projections.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000006646</identifier><identifier>PMID: 30429273</identifier><language>eng</language><publisher>United States: American Academy of Neurology</publisher><subject>Aged ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - diagnostic imaging ; Cognitive Dysfunction - pathology ; Corpus Callosum - diagnostic imaging ; Corpus Callosum - pathology ; Diffusion Tensor Imaging ; Female ; Humans ; Male ; Neuropsychological Tests ; Parkinson Disease - complications ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - pathology ; White Matter - diagnostic imaging ; White Matter - pathology</subject><ispartof>Neurology, 2018-12, Vol.91 (24), p.e2244-e2255</ispartof><rights>2018 American Academy of Neurology</rights><rights>2018 American Academy of Neurology.</rights><rights>2018 American Academy of Neurology 2018 American Academy of Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5536-c3b49ca244e1d29f52da7ac83e3765ac91cff192f75f2bb02f86368106a1da0c3</citedby><cites>FETCH-LOGICAL-c5536-c3b49ca244e1d29f52da7ac83e3765ac91cff192f75f2bb02f86368106a1da0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30429273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bledsoe, Ian O</creatorcontrib><creatorcontrib>Stebbins, Glenn T</creatorcontrib><creatorcontrib>Merkitch, Doug</creatorcontrib><creatorcontrib>Goldman, Jennifer G</creatorcontrib><title>White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease</title><title>Neurology</title><addtitle>Neurology</addtitle><description>OBJECTIVETo evaluate microstructural characteristics of the corpus callosum using diffusion tensor imaging (DTI) and their relationships to cognitive impairment in Parkinson disease (PD).
METHODSSeventy-five participants with PD and 24 healthy control (HC) participants underwent structural MRI brain scans including DTI sequences and clinical and neuropsychological evaluations. Using Movement Disorder Society criteria, PD participants were classified as having normal cognition (PD-NC, n = 23), mild cognitive impairment (PD-MCI, n = 35), or dementia (PDD, n = 17). Cognitive domain (attention/working memory, executive function, language, memory, visuospatial function) z scores were calculated. DTI scalar values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were established for 5 callosal segments on a midsagittal plane, single slice using a topographically derived parcellation method. Scalar values were compared among participant groups. Regression analyses were performed on cognitive domain z scores and DTI metrics.
RESULTSParticipants with PD showed increased AD values in the anterior 3 callosal segments compared to healthy controls. Participants with PDD had significantly increased AD, MD, and RD in the anterior 2 segments compared to participants with PD-NC and most anterior segment compared to participants with PD-MCI. FA values did not differ significantly between participants with PD and participants with HC or among PD cognitive groups. The strongest associations for the DTI metrics and cognitive performance occurred in the most anterior and most posterior callosal segments, and also reflected fronto-striatal and posterior cortical type cognitive deficits, respectively.
CONCLUSIONSMicrostructural white matter abnormalities of the corpus callosum, as measured by DTI, may contribute to PD cognitive impairment by disrupting information transfer across interhemispheric and callosal–cortical projections.</description><subject>Aged</subject><subject>Cognitive Dysfunction - complications</subject><subject>Cognitive Dysfunction - diagnostic imaging</subject><subject>Cognitive Dysfunction - pathology</subject><subject>Corpus Callosum - diagnostic imaging</subject><subject>Corpus Callosum - pathology</subject><subject>Diffusion Tensor Imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Neuropsychological Tests</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - pathology</subject><subject>White Matter - diagnostic imaging</subject><subject>White Matter - pathology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS1ERaeFN0AoSzYp_kkcZ4OEqkKRRtAFqOzMjXPTmDrxYDsd9e3rYUpVWIA3lu79zvGRDyEvGT1hnPE3l5_WJ_TRkbKST8iK1VyWUvBvT8mKUq5KoRp1SI5i_EFpXjbtM3IoaMVb3ogV-X452oTFBClhKKCbfZjA2WQxFnYu0oiF8WGzxMKAcz4uU7G1aczDqzlTN1jYaQM2TDinneACwrWdo5-L3kaEiM_JwQAu4ov7-5h8fX_25fS8XH_-8PH03bo0dS1kaURXtQZ4VSHreTvUvIcGjBIoGlmDaZkZBtbyoakH3nWUD0oKqRiVwHqgRhyTt3vfzdJN2JucJ4DTm2AnCLfag9V_bmY76it_o_NftYLX2eD1vUHwPxeMSU82GnQOZvRL1JwJoXI-rjJa7VETfIwBh4dnGNW7cnQuR_9dTpa9ehzxQfS7jQyoPbD1LtcRr92yxaBHBJfG_3lX_5D-whirSk6ZyiaMlrtRK-4ApY2uEw</recordid><startdate>20181211</startdate><enddate>20181211</enddate><creator>Bledsoe, Ian O</creator><creator>Stebbins, Glenn T</creator><creator>Merkitch, Doug</creator><creator>Goldman, Jennifer G</creator><general>American Academy of Neurology</general><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181211</creationdate><title>White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease</title><author>Bledsoe, Ian O ; Stebbins, Glenn T ; Merkitch, Doug ; Goldman, Jennifer G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5536-c3b49ca244e1d29f52da7ac83e3765ac91cff192f75f2bb02f86368106a1da0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Cognitive Dysfunction - complications</topic><topic>Cognitive Dysfunction - diagnostic imaging</topic><topic>Cognitive Dysfunction - pathology</topic><topic>Corpus Callosum - diagnostic imaging</topic><topic>Corpus Callosum - pathology</topic><topic>Diffusion Tensor Imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Neuropsychological Tests</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - pathology</topic><topic>White Matter - diagnostic imaging</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bledsoe, Ian O</creatorcontrib><creatorcontrib>Stebbins, Glenn T</creatorcontrib><creatorcontrib>Merkitch, Doug</creatorcontrib><creatorcontrib>Goldman, Jennifer G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bledsoe, Ian O</au><au>Stebbins, Glenn T</au><au>Merkitch, Doug</au><au>Goldman, Jennifer G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2018-12-11</date><risdate>2018</risdate><volume>91</volume><issue>24</issue><spage>e2244</spage><epage>e2255</epage><pages>e2244-e2255</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>OBJECTIVETo evaluate microstructural characteristics of the corpus callosum using diffusion tensor imaging (DTI) and their relationships to cognitive impairment in Parkinson disease (PD).
METHODSSeventy-five participants with PD and 24 healthy control (HC) participants underwent structural MRI brain scans including DTI sequences and clinical and neuropsychological evaluations. Using Movement Disorder Society criteria, PD participants were classified as having normal cognition (PD-NC, n = 23), mild cognitive impairment (PD-MCI, n = 35), or dementia (PDD, n = 17). Cognitive domain (attention/working memory, executive function, language, memory, visuospatial function) z scores were calculated. DTI scalar values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), were established for 5 callosal segments on a midsagittal plane, single slice using a topographically derived parcellation method. Scalar values were compared among participant groups. Regression analyses were performed on cognitive domain z scores and DTI metrics.
RESULTSParticipants with PD showed increased AD values in the anterior 3 callosal segments compared to healthy controls. Participants with PDD had significantly increased AD, MD, and RD in the anterior 2 segments compared to participants with PD-NC and most anterior segment compared to participants with PD-MCI. FA values did not differ significantly between participants with PD and participants with HC or among PD cognitive groups. The strongest associations for the DTI metrics and cognitive performance occurred in the most anterior and most posterior callosal segments, and also reflected fronto-striatal and posterior cortical type cognitive deficits, respectively.
CONCLUSIONSMicrostructural white matter abnormalities of the corpus callosum, as measured by DTI, may contribute to PD cognitive impairment by disrupting information transfer across interhemispheric and callosal–cortical projections.</abstract><cop>United States</cop><pub>American Academy of Neurology</pub><pmid>30429273</pmid><doi>10.1212/WNL.0000000000006646</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Cognitive Dysfunction - complications Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - pathology Corpus Callosum - diagnostic imaging Corpus Callosum - pathology Diffusion Tensor Imaging Female Humans Male Neuropsychological Tests Parkinson Disease - complications Parkinson Disease - diagnostic imaging Parkinson Disease - pathology White Matter - diagnostic imaging White Matter - pathology |
| title | White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease |
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