Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome
Renin angiotensin system (RAS) plays a role in idiopathic nephrotic syndrome (INS). Most studies investigated only the classical RAS axis. Therefore, the aims of the present study were to evaluate urinary levels of RAS molecules related to classical and to counter-regulatory axes in pediatric patien...
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| description | Renin angiotensin system (RAS) plays a role in idiopathic nephrotic syndrome (INS). Most studies investigated only the classical RAS axis. Therefore, the aims of the present study were to evaluate urinary levels of RAS molecules related to classical and to counter-regulatory axes in pediatric patients with INS, to compare the measurements with levels in healthy controls and to search for associations with inflammatory molecules, proteinuria and disease treatment.
This cross-sectional study included 31 patients with INS and 19 healthy controls, matched for age and sex. Patients and controls were submitted to urine collection for measurement of RAS molecules [Ang II, Ang-(1-7), ACE and ACE2] by enzyme immunoassay and cytokines by Cytometric Bead Array. Findings in INS patients were compared according to proteinuria: absent ( |
| doi_str_mv | 10.1042/BSR20181361 |
| format | Article |
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This cross-sectional study included 31 patients with INS and 19 healthy controls, matched for age and sex. Patients and controls were submitted to urine collection for measurement of RAS molecules [Ang II, Ang-(1-7), ACE and ACE2] by enzyme immunoassay and cytokines by Cytometric Bead Array. Findings in INS patients were compared according to proteinuria: absent (<150 mg/dl,
= 15) and present (≥150 mg/dl,
= 16).
In comparison to controls, INS patients had increased Ang II, Ang-(1-7) and ACE, levels while ACE2 was reduced. INS patients with proteinuria had lower levels of ACE2 than those without proteinuria. ACE2 levels were negatively correlated with 24-h-proteinuria. Urinary concentrations of MCP-1/CCL2 were significantly higher in INS patients, positively correlated with Ang II and negatively with Ang-(1-7). ACE2 concentrations were negatively correlated with IP-10/CXCL-10 levels, which, in turn, were positively correlated with 24-h-proteinuria.
INS patients exhibited changes in RAS molecules and in chemokines. Proteinuria was associated with low levels of ACE2 and high levels of inflammatory molecules.</description><identifier>ISSN: 0144-8463</identifier><identifier>EISSN: 1573-4935</identifier><identifier>DOI: 10.1042/BSR20181361</identifier><identifier>PMID: 30514826</identifier><language>eng</language><publisher>England: Portland Press Ltd</publisher><subject>Adolescent ; Angiotensin I - genetics ; Angiotensin I - urine ; Angiotensin II - genetics ; Angiotensin II - urine ; Animals ; Case-Control Studies ; Chemokine CCL2 - genetics ; Chemokine CCL2 - urine ; Chemokine CXCL10 - genetics ; Chemokine CXCL10 - urine ; Child ; Cross-Sectional Studies ; Female ; Gene Expression ; Humans ; Male ; Nephrotic Syndrome - diagnosis ; Nephrotic Syndrome - genetics ; Nephrotic Syndrome - pathology ; Nephrotic Syndrome - urine ; Peptide Fragments - genetics ; Peptide Fragments - urine ; Peptidyl-Dipeptidase A - genetics ; Peptidyl-Dipeptidase A - urine ; Proteinuria - diagnosis ; Proteinuria - genetics ; Proteinuria - pathology ; Proteinuria - urine ; Renin-Angiotensin System - genetics</subject><ispartof>Bioscience reports, 2019-01, Vol.39 (1)</ispartof><rights>2019 The Author(s).</rights><rights>2019 The Author(s). 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-efd76b69cd5d332abcec80278fb06ef9697e1fea4700934429f2df91c793e6cc3</citedby><cites>FETCH-LOGICAL-c381t-efd76b69cd5d332abcec80278fb06ef9697e1fea4700934429f2df91c793e6cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328887/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328887/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30514826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filha, Roberta da Silva</creatorcontrib><creatorcontrib>Pinheiro, Sérgio Veloso Brant</creatorcontrib><creatorcontrib>Macedo E Cordeiro, Thiago</creatorcontrib><creatorcontrib>Feracin, Victor</creatorcontrib><creatorcontrib>Vieira, Érica Leandro Marciano</creatorcontrib><creatorcontrib>Miranda, Aline Silva</creatorcontrib><creatorcontrib>Simões E Silva, Ana Cristina</creatorcontrib><title>Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome</title><title>Bioscience reports</title><addtitle>Biosci Rep</addtitle><description>Renin angiotensin system (RAS) plays a role in idiopathic nephrotic syndrome (INS). Most studies investigated only the classical RAS axis. Therefore, the aims of the present study were to evaluate urinary levels of RAS molecules related to classical and to counter-regulatory axes in pediatric patients with INS, to compare the measurements with levels in healthy controls and to search for associations with inflammatory molecules, proteinuria and disease treatment.
This cross-sectional study included 31 patients with INS and 19 healthy controls, matched for age and sex. Patients and controls were submitted to urine collection for measurement of RAS molecules [Ang II, Ang-(1-7), ACE and ACE2] by enzyme immunoassay and cytokines by Cytometric Bead Array. Findings in INS patients were compared according to proteinuria: absent (<150 mg/dl,
= 15) and present (≥150 mg/dl,
= 16).
In comparison to controls, INS patients had increased Ang II, Ang-(1-7) and ACE, levels while ACE2 was reduced. INS patients with proteinuria had lower levels of ACE2 than those without proteinuria. ACE2 levels were negatively correlated with 24-h-proteinuria. Urinary concentrations of MCP-1/CCL2 were significantly higher in INS patients, positively correlated with Ang II and negatively with Ang-(1-7). ACE2 concentrations were negatively correlated with IP-10/CXCL-10 levels, which, in turn, were positively correlated with 24-h-proteinuria.
INS patients exhibited changes in RAS molecules and in chemokines. Proteinuria was associated with low levels of ACE2 and high levels of inflammatory molecules.</description><subject>Adolescent</subject><subject>Angiotensin I - genetics</subject><subject>Angiotensin I - urine</subject><subject>Angiotensin II - genetics</subject><subject>Angiotensin II - urine</subject><subject>Animals</subject><subject>Case-Control Studies</subject><subject>Chemokine CCL2 - genetics</subject><subject>Chemokine CCL2 - urine</subject><subject>Chemokine CXCL10 - genetics</subject><subject>Chemokine CXCL10 - urine</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Male</subject><subject>Nephrotic Syndrome - diagnosis</subject><subject>Nephrotic Syndrome - genetics</subject><subject>Nephrotic Syndrome - pathology</subject><subject>Nephrotic Syndrome - urine</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - urine</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Peptidyl-Dipeptidase A - urine</subject><subject>Proteinuria - diagnosis</subject><subject>Proteinuria - genetics</subject><subject>Proteinuria - pathology</subject><subject>Proteinuria - urine</subject><subject>Renin-Angiotensin System - genetics</subject><issn>0144-8463</issn><issn>1573-4935</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1LJDEQxYO46Kx68i45CtJuvjqdvgg6uLogLKx6Dpl0ZSbSnbRJz8DsX2_ED_SUIu9Xr6p4CB1Tck6JYL-u7v8xQhXlku6gGa0bXomW17toRqgQlRKS76OfOT8RQoog9tA-JzUViskZctcb30GwgF1M2OAUe8DRYROWPk4Qsg_YxrCBNPmwxBD-bwfADJfvMRXAh3Xy5rXDdz6OZlp5iwOMqyKWKm9Dl-IAh-iHM32Go_f3AD3-vn6Y31Z3f2_-zC_vKssVnSpwXSMXsrVd3XHOzMKCVYQ1yi2IBNfKtgHqwIiGkHKJYK1jnWupbVoO0lp-gC7efMf1YoDOQpiS6fWY_GDSVkfj9Xcl-JVexo2WnCmlmmJw-m6Q4vMa8qQHny30vQkQ11kzWpOa1S2nBT17Q22KOSdwn2Mo0a_J6C_JFPrk62af7EcU_AVBV4vm</recordid><startdate>20190131</startdate><enddate>20190131</enddate><creator>Filha, Roberta da Silva</creator><creator>Pinheiro, Sérgio Veloso Brant</creator><creator>Macedo E Cordeiro, Thiago</creator><creator>Feracin, Victor</creator><creator>Vieira, Érica Leandro Marciano</creator><creator>Miranda, Aline Silva</creator><creator>Simões E Silva, Ana Cristina</creator><general>Portland Press Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190131</creationdate><title>Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome</title><author>Filha, Roberta da Silva ; Pinheiro, Sérgio Veloso Brant ; Macedo E Cordeiro, Thiago ; Feracin, Victor ; Vieira, Érica Leandro Marciano ; Miranda, Aline Silva ; Simões E Silva, Ana Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-efd76b69cd5d332abcec80278fb06ef9697e1fea4700934429f2df91c793e6cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Angiotensin I - genetics</topic><topic>Angiotensin I - urine</topic><topic>Angiotensin II - genetics</topic><topic>Angiotensin II - urine</topic><topic>Animals</topic><topic>Case-Control Studies</topic><topic>Chemokine CCL2 - genetics</topic><topic>Chemokine CCL2 - urine</topic><topic>Chemokine CXCL10 - genetics</topic><topic>Chemokine CXCL10 - urine</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Male</topic><topic>Nephrotic Syndrome - diagnosis</topic><topic>Nephrotic Syndrome - genetics</topic><topic>Nephrotic Syndrome - pathology</topic><topic>Nephrotic Syndrome - urine</topic><topic>Peptide Fragments - genetics</topic><topic>Peptide Fragments - urine</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Peptidyl-Dipeptidase A - urine</topic><topic>Proteinuria - diagnosis</topic><topic>Proteinuria - genetics</topic><topic>Proteinuria - pathology</topic><topic>Proteinuria - urine</topic><topic>Renin-Angiotensin System - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filha, Roberta da Silva</creatorcontrib><creatorcontrib>Pinheiro, Sérgio Veloso Brant</creatorcontrib><creatorcontrib>Macedo E Cordeiro, Thiago</creatorcontrib><creatorcontrib>Feracin, Victor</creatorcontrib><creatorcontrib>Vieira, Érica Leandro Marciano</creatorcontrib><creatorcontrib>Miranda, Aline Silva</creatorcontrib><creatorcontrib>Simões E Silva, Ana Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioscience reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filha, Roberta da Silva</au><au>Pinheiro, Sérgio Veloso Brant</au><au>Macedo E Cordeiro, Thiago</au><au>Feracin, Victor</au><au>Vieira, Érica Leandro Marciano</au><au>Miranda, Aline Silva</au><au>Simões E Silva, Ana Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome</atitle><jtitle>Bioscience reports</jtitle><addtitle>Biosci Rep</addtitle><date>2019-01-31</date><risdate>2019</risdate><volume>39</volume><issue>1</issue><issn>0144-8463</issn><eissn>1573-4935</eissn><abstract>Renin angiotensin system (RAS) plays a role in idiopathic nephrotic syndrome (INS). Most studies investigated only the classical RAS axis. Therefore, the aims of the present study were to evaluate urinary levels of RAS molecules related to classical and to counter-regulatory axes in pediatric patients with INS, to compare the measurements with levels in healthy controls and to search for associations with inflammatory molecules, proteinuria and disease treatment.
This cross-sectional study included 31 patients with INS and 19 healthy controls, matched for age and sex. Patients and controls were submitted to urine collection for measurement of RAS molecules [Ang II, Ang-(1-7), ACE and ACE2] by enzyme immunoassay and cytokines by Cytometric Bead Array. Findings in INS patients were compared according to proteinuria: absent (<150 mg/dl,
= 15) and present (≥150 mg/dl,
= 16).
In comparison to controls, INS patients had increased Ang II, Ang-(1-7) and ACE, levels while ACE2 was reduced. INS patients with proteinuria had lower levels of ACE2 than those without proteinuria. ACE2 levels were negatively correlated with 24-h-proteinuria. Urinary concentrations of MCP-1/CCL2 were significantly higher in INS patients, positively correlated with Ang II and negatively with Ang-(1-7). ACE2 concentrations were negatively correlated with IP-10/CXCL-10 levels, which, in turn, were positively correlated with 24-h-proteinuria.
INS patients exhibited changes in RAS molecules and in chemokines. Proteinuria was associated with low levels of ACE2 and high levels of inflammatory molecules.</abstract><cop>England</cop><pub>Portland Press Ltd</pub><pmid>30514826</pmid><doi>10.1042/BSR20181361</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Angiotensin I - genetics Angiotensin I - urine Angiotensin II - genetics Angiotensin II - urine Animals Case-Control Studies Chemokine CCL2 - genetics Chemokine CCL2 - urine Chemokine CXCL10 - genetics Chemokine CXCL10 - urine Child Cross-Sectional Studies Female Gene Expression Humans Male Nephrotic Syndrome - diagnosis Nephrotic Syndrome - genetics Nephrotic Syndrome - pathology Nephrotic Syndrome - urine Peptide Fragments - genetics Peptide Fragments - urine Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - urine Proteinuria - diagnosis Proteinuria - genetics Proteinuria - pathology Proteinuria - urine Renin-Angiotensin System - genetics |
| title | Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome |
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