Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer
Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic proper...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-16 |
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| creator | Xu, Wenrong Mao, Fei Zhang, Xu Yan, Yongmin Yang, Yanhui Wang, Gaoying Ma, Xiangyu Luo, Xiao Zhang, Li Kang, Jingjing Qian, Hui |
| description | Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD. The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions. One of the promising therapeutic options for IBD can focus on exosomes of MSCs. MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition. Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved. This review can assist investigators better to understand the research progress for enhancing the efficacy of MSCs therapy involved in IBD and CAC. |
| doi_str_mv | 10.1155/2018/9652817 |
| format | Article |
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Different sources of MSCs show different therapeutic properties. Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD. The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions. One of the promising therapeutic options for IBD can focus on exosomes of MSCs. MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition. Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved. This review can assist investigators better to understand the research progress for enhancing the efficacy of MSCs therapy involved in IBD and CAC.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/9652817</identifier><identifier>PMID: 30687760</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Cancer ; Cancer therapies ; Clinical trials ; Colon ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - pathology ; Exosomes ; Homing ; Humans ; Immune response ; Immune system ; Immunomodulation ; Immunomodulation - physiology ; Immunosuppression ; Immunosuppression Therapy - methods ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - pathology ; Intestine ; Lesions ; Medical research ; Mesenchymal Stem Cell Transplantation - methods ; Mesenchymal Stem Cells - pathology ; Mesenchyme ; Paracrine signalling ; Pathogenesis ; Review ; Stem cells ; Therapy ; Umbilical cord ; Wound healing</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-16</ispartof><rights>Copyright © 2018 Jingjing Kang et al.</rights><rights>Copyright © 2018 Jingjing Kang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Jingjing Kang et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-2069b7fce7c057d840f2244b6ddfad648a8aac9e708a033a70c3f42a236b6ae23</citedby><cites>FETCH-LOGICAL-c471t-2069b7fce7c057d840f2244b6ddfad648a8aac9e708a033a70c3f42a236b6ae23</cites><orcidid>0000-0001-5840-4436 ; 0000-0003-3492-4618 ; 0000-0003-0903-1973 ; 0000-0001-7023-8186 ; 0000-0002-0098-3196</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327253/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327253/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30687760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chiba, Toshimi</contributor><contributor>Toshimi Chiba</contributor><creatorcontrib>Xu, Wenrong</creatorcontrib><creatorcontrib>Mao, Fei</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Yan, Yongmin</creatorcontrib><creatorcontrib>Yang, Yanhui</creatorcontrib><creatorcontrib>Wang, Gaoying</creatorcontrib><creatorcontrib>Ma, Xiangyu</creatorcontrib><creatorcontrib>Luo, Xiao</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Kang, Jingjing</creatorcontrib><creatorcontrib>Qian, Hui</creatorcontrib><title>Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Mesenchymal stem cells (MSCs) therapy has been applied to a wide range of diseases with excessive immune response, including inflammatory bowel disease (IBD), owing to its powerful immunosuppression and its ability to repair tissue lesions. Different sources of MSCs show different therapeutic properties. Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD. The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions. One of the promising therapeutic options for IBD can focus on exosomes of MSCs. MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition. Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved. 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Different sources of MSCs show different therapeutic properties. Engineering managements are able to enhance the immunomodulation function and the survival of MSCs involved in IBD. The therapeutic mechanism of MSCs in IBD mainly focuses on cell-to-cell contact and paracrine actions. One of the promising therapeutic options for IBD can focus on exosomes of MSCs. MSCs hold promise for the treatment of IBD-associated colorectal cancer because of their tumor-homing function and chronic inflammation inhibition. Encouraging results have been obtained from clinical trials in IBD and potential challenges caused by MSCs therapy are getting solved. 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| subjects | Animals Cancer Cancer therapies Clinical trials Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Exosomes Homing Humans Immune response Immune system Immunomodulation Immunomodulation - physiology Immunosuppression Immunosuppression Therapy - methods Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - pathology Intestine Lesions Medical research Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells - pathology Mesenchyme Paracrine signalling Pathogenesis Review Stem cells Therapy Umbilical cord Wound healing |
| title | Systematic Exposition of Mesenchymal Stem Cell for Inflammatory Bowel Disease and Its Associated Colorectal Cancer |
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