Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization

Abstract Background Zika virus (ZIKV) infection has been associated with prolonged viral excretion in human semen and causes testicular atrophy and infertility in 10-week-old immunodeficient mice. Methods Male IFNAR−/− mice, knockout for type I interferon receptor, were immunized with GLS-5700, a de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infectious diseases 2019-01, Vol.219 (3), p.365-374
Hauptverfasser:	de La Vega, Marc-Antoine, Piret, Jocelyne, Griffin, Bryan D., Rhéaume, Chantal, Venable, Marie-Christine, Carbonneau, Julie, Couture, Christian, Almeida, Raquel das Neves, Tremblay, Roland R., Magalhães, Kelly G., Park, Young K., Roberts, Christine C., Maslow, Joel N., Sardesai, Niranjan Y., Kim, J. Joseph, Muthumani, Kar, Weiner, David B., Kobinger, Gary P., Boivin, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy Atrophy - etiology Deoxyribonucleic acid Disease Models, Animal DNA DNA - pharmacology Epididymis - pathology Female Fertility Immunization Immunodeficiency Infections Infertility Infertility, Male - drug therapy Infertility, Male - etiology Infertility, Male - prevention & control Interferon Major and Brief Reports Male Males Mice Mice, Inbred C57BL Mice, Knockout Mice, SCID Receptor, Interferon alpha-beta - genetics Semen Sexual Behavior, Animal Sperm Count Sperm Motility Spermatozoa Testis - pathology Vaccination Viremia VIRUSES Zika virus Zika Virus Infection - complications
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!