Cytokines in clinical cancer immunotherapy

Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal models, clinical research led to the approval of recombinant interferon-alpha and interleukin-2 for the treatment of sev...

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Veröffentlicht in:	British journal of cancer 2019-01, Vol.120 (1), p.6-15
Hauptverfasser:	Berraondo, Pedro, Sanmamed, Miguel F., Ochoa, María C, Etxeberria, Iñaki, Aznar, Maria A., Pérez-Gracia, José Luis, Rodríguez-Ruiz, María E., Ponz-Sarvise, Mariano, Castañón, Eduardo, Melero, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/250/251 692/308/153 Animal models Antibodies Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Cancer immunotherapy Cancer Research Cell interactions Chemical compounds Chimeric antigen receptors Clinical trials Cytokines Cytokines - immunology Cytokines - therapeutic use Drug development Drug Resistance Effector cells Epidemiology Humans Immune checkpoint Immunomodulation Immunosuppressive agents Immunotherapy Immunotherapy, Adoptive Inflammation Interferon Interferon-alpha - genetics Interferon-alpha - immunology Interferon-alpha - therapeutic use Interleukin 2 Interleukin-2 - genetics Interleukin-2 - immunology Interleukin-2 - therapeutic use Lymphocytes Lymphocytes T Molecular Medicine Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy Oncology Proteins Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - immunology Review Review Article siRNA Tumor microenvironment Tumor Microenvironment - immunology Tumors α-Interferon
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