Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis

Bacterial cell division requires identification of the division site, assembly of the division machinery, and constriction of the cell envelope. These processes are regulated in response to several cellular and environmental signals. Here, we use small molecule iron chelators to characterize the sur...

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Veröffentlicht in:	ACS chemical biology 2018-01, Vol.13 (1), p.235-246
Hauptverfasser:	Santos, Thiago M. A, Lammers, Matthew G, Zhou, Maoquan, Sparks, Ian L, Rajendran, Madhusudan, Fang, Dong, De Jesus, Crystal L. Y, Carneiro, Gabriel F. R, Cui, Qiang, Weibel, Douglas B
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - cytology Bacteria - drug effects Bacteria - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Benzimidazoles - metabolism Benzimidazoles - pharmacology Caulobacter crescentus - cytology Caulobacter crescentus - drug effects Caulobacter crescentus - metabolism Cobalt - pharmacology Copper - pharmacology Cytokinesis - drug effects Escherichia coli - cytology Escherichia coli - drug effects Escherichia coli - metabolism Gene Expression Regulation, Bacterial - drug effects Hydrazines - metabolism Hydrazines - pharmacology Iron - metabolism Iron - pharmacology Iron Chelating Agents - metabolism Iron Chelating Agents - pharmacology Naphthalenes - metabolism Naphthalenes - pharmacology Peptidoglycan - metabolism
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