The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes

During an adaptive immune response, activated mature B cells give rise to Ab-secreting plasma cells to fight infection. B cells undergo Ab class switching to produce different classes of Abs with varying effector functions. The mammalian/mechanistic target of rapamycin (mTOR) signaling pathway is ac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2019-01, Vol.202 (2), p.579-590
Hauptverfasser:	Chiu, Honyin, Jackson, Leandra V, Oh, Kwon Ik, Mai, Annie, Ronai, Ze'ev A, Ruggero, Davide, Fruman, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals B-Lymphocytes - drug effects B-Lymphocytes - immunology Carrier Proteins - genetics Carrier Proteins - immunology Cell Cycle Proteins Cells, Cultured Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - immunology Eukaryotic Initiation Factors Gene Expression Regulation Immunoglobulin Class Switching Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - immunology Mice Mice, Inbred C57BL Mice, Transgenic Phosphoproteins - genetics Phosphoproteins - immunology Protein Binding Protein Biosynthesis Signal Transduction Sirolimus - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!