A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF

Correct localization of Rab GTPases in cells is critical for proper function in membrane trafficking, yet the mechanisms that target Rabs to specific subcellular compartments remain controversial. Guanine nucleotide exchange factors (GEFs) activate and consequently stabilize Rab substrates on membra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Developmental cell 2019-01, Vol.48 (1), p.100-114.e9
Hauptverfasser:	Thomas, Laura L., van der Vegt, Solveig A., Fromme, J. Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	GEF Golgi GTPase Humans Mutation - genetics Protein Transport - physiology Rab rab GTP-Binding Proteins - metabolism Rab-GEF Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Signal Transduction - physiology Substrate Specificity - physiology trafficking TRAPP Vesicular Transport Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!