Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria

Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. To examine the association of impaired CYP2D6 ge...

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Veröffentlicht in:	JAMA network open 2018-08, Vol.1 (4), p.e181449-e181449
Hauptverfasser:	Baird, J Kevin, Louisa, Melva, Noviyanti, Rintis, Ekawati, Lenny, Elyazar, Iqbal, Subekti, Decy, Chand, Krisin, Gayatri, Anggi, Instiaty, Soebianto, Saraswati, Crenna-Darusallam, Chelzie, Djoko, Dwi, Hasto, Bambang Dwi, Meriyenes, Dubel, Wesche, David, Nelwan, Erni J, Sutanto, Inge, Sudoyo, Herawati, Setiabudy, Rianto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimalarials - pharmacology Antimalarials - therapeutic use Case-Control Studies Clinical trials Cytochrome Cytochrome P-450 CYP2D6 - genetics Female Genotype Genotype & phenotype Humans Infectious Diseases Malaria Malaria, Vivax - drug therapy Male Metabolism Middle Aged Online Only Original Investigation Phenotype Plasmodium vivax - drug effects Plasmodium vivax - genetics Primaquine - pharmacology Primaquine - therapeutic use Treatment Outcome Young Adult
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