GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology

Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of human genetics 2019-01, Vol.104 (1), p.157-163
Hauptverfasser:	Bovijn, Jonas, Jackson, Leigh, Censin, Jenny, Chen, Chia-Yen, Laisk, Triin, Laber, Samantha, Ferreira, Teresa, Pulit, Sara L., Glastonbury, Craig A., Smoller, Jordan W., Harrison, Jamie W., Ruth, Katherine S., Beaumont, Robin N., Jones, Samuel E., Tyrrell, Jessica, Wood, Andrew R., Weedon, Michael N., Mägi, Reedik, Neale, Benjamin, Lindgren, Cecilia M., Murray, Anna, Holmes, Michael V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Basic Helix-Loop-Helix Transcription Factors - genetics Chromosomes, Human, Pair 6 - genetics Computer Simulation diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics erectile dysfunction Erectile Dysfunction - etiology Erectile Dysfunction - genetics Europe Genetic Predisposition to Disease genome-wide association Genome-Wide Association Study GWAS Humans Hypothalamus - pathology impotence Male mendelian randomisation Mendelian randomization Repressor Proteins - genetics SIM1 UK biobank
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!