Suppressing protein Z‐dependent inhibition of factor Xa improves coagulation in hemophilia A

Essentials Protein Z (PZ) catalyzes PZ‐dependent proteinase inhibitor (ZPI) inactivation of factor (F)Xa. Gene‐deletion of PZ or ZPI improves coagulation in hemophilia (FVIII knockout) mice. A PZ blocking antibody enhances thrombin generation in human hemophilia plasma. Suppression of the PZ/ZPI pat...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2019-01, Vol.17 (1), p.149-156
Hauptverfasser:	Girard, T. J., Lasky, N. M., Grunz, K., Broze, G. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Anticoagulants blood coagulation Blood Coagulation - drug effects Blood Proteins - antagonists & inhibitors Blood Proteins - deficiency Blood Proteins - genetics Blood Proteins - metabolism Coagulants - pharmacology Coagulation factors Disease Models, Animal factor VIII Factor VIII - genetics Factor VIII - metabolism Factor Xa - metabolism Gene deletion Genetic Predisposition to Disease Hemophilia hemophilia A Hemophilia A - blood Hemophilia A - drug therapy Hemophilia A - genetics Hemostasis Humans mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Phenotype Phenotypes Phospholipids Plasma Proof of Concept Study Proteinase inhibitors Serpins - deficiency Serpins - genetics Serpins - metabolism Thrombin Thrombin - metabolism
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